Role of Genomics in the Management of Hypertension
Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide associa...
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| Year of Publication: | 2020 |
| Language: | English |
| Physical Description: | 1 electronic resource (200 p.) |
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(CKB)5400000000045926 (oapen)https://directory.doabooks.org/handle/20.500.12854/68974 (EXLCZ)995400000000045926 |
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Mulatero, Paolo edt Role of Genomics in the Management of Hypertension Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 1 electronic resource (200 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field. English Research & information: general bicssc Biology, life sciences bicssc atrial natriuretic peptide T2238C variant endothelial dysfunction smooth muscle cells contraction platelet aggregation epigenetics cardiovascular diseases renin low-renin hypertension mineralocorticoid receptor genetics aldosterone essential hypertension blood pressure genome-wide association studies exome microarray next-generation sequencing rare variants rare-variants association testing burden test sequence kernel association test hypokalemia low renin hypertension monogenic hypertension Liddle syndrome SCNN1A SCNN1B SCNN1G non-coding RNA micro RNA primary aldosteronism aldosterone-producing adenoma transcriptome profiing DNA methylation histone modifications vascular smooth muscle cells endothelial cells Kruppel-like factor 15 left ventricular hypertrophy cardiac hypertrophy heart failure genetics of left ventricular hypertrophy fibromuscular dysplasia non atherosclerotic vascular stenosis PHACTR1 genetic association cervical artery dissection spontaneous coronary arteries dissection CRY1 CRY2 HSD3B1 HSD3B2 cardio-tonic steroids endogenous ouabain adducin renal damage African American ARMC5 GRK4 CACNA1D endocrine hypertension 3-03936-627-0 3-03936-628-9 Monticone, Silvia edt Mulatero, Paolo oth Monticone, Silvia oth |
| language |
English |
| format |
eBook |
| author2 |
Monticone, Silvia Mulatero, Paolo Monticone, Silvia |
| author_facet |
Monticone, Silvia Mulatero, Paolo Monticone, Silvia |
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p m pm s m sm |
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HerausgeberIn Sonstige Sonstige |
| title |
Role of Genomics in the Management of Hypertension |
| spellingShingle |
Role of Genomics in the Management of Hypertension |
| title_full |
Role of Genomics in the Management of Hypertension |
| title_fullStr |
Role of Genomics in the Management of Hypertension |
| title_full_unstemmed |
Role of Genomics in the Management of Hypertension |
| title_auth |
Role of Genomics in the Management of Hypertension |
| title_new |
Role of Genomics in the Management of Hypertension |
| title_sort |
role of genomics in the management of hypertension |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2020 |
| physical |
1 electronic resource (200 p.) |
| isbn |
3-03936-627-0 3-03936-628-9 |
| illustrated |
Not Illustrated |
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Role of Genomics in the Management of Hypertension |
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