Drug Delivery of siRNA Therapeutics
The new frontier of pharmaceutical sciences is gene therapy, which is the use of molecules able to interact directly with the expression of the genetic material of the patient as well as of the disease-causing guest (bacteria, virus, parasites, and tumor cells). Among the molecules of interest for g...
Saved in:
HerausgeberIn: | |
---|---|
Sonstige: | |
Year of Publication: | 2020 |
Language: | English |
Physical Description: | 1 electronic resource (288 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993545996204498 |
---|---|
ctrlnum |
(CKB)5400000000042842 (oapen)https://directory.doabooks.org/handle/20.500.12854/68603 (EXLCZ)995400000000042842 |
collection |
bib_alma |
record_format |
marc |
spelling |
Lamberti, Gaetano edt Drug Delivery of siRNA Therapeutics Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 1 electronic resource (288 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier The new frontier of pharmaceutical sciences is gene therapy, which is the use of molecules able to interact directly with the expression of the genetic material of the patient as well as of the disease-causing guest (bacteria, virus, parasites, and tumor cells). Among the molecules of interest for gene therapy, a relevant role is played by small interfering RNA (siRNA) molecules able to interfere with the expression of genes of interest for some diseases. However, siRNA molecules, even if they are powerful as drugs, are difficult to deliver since they are sensitive to enzymes present in plasma and they are large and negatively charged, so are difficult to administer into the cell nuclei, since the cell walls are scarcely permeable to large molecules and are also negatively charged. Therefore, the focus of research on siRNA-based therapies is their delivery, which can be performed by chemical modification, association with aptamers or polycations, or embedding them into properly designed liposomes. This book is centered on the more recent development in siRNA delivery techniques toward the clinical applications of this potent class of drugs. English Medicine bicssc oligonucleotide delivery light-activated release intracellular release liposome indocyanine green drug co-delivery methotrexate siRNA antitumor effect mixed micelles targeted delivery system cationic liposome folate folate receptor cationic cholesterol derivative siRNA delivery gene knockdown tumor-targeting VEGFA VEGFR1 endoglin peptide angiogenesis gene silencing migration proliferation endothelial cells RNAi therapeutics amphiphilic dendrons PAMAM dendrimers self-assembling nanovectors covalent dendrimers NABDs liposomes clinical trials drug delivery nanoparticle carbonate apatite ERBB2 AKT breast cancer ovarian cancer polymer lipid delivery poly(ethylene) imine PEI RNA tyrosine-modification tumor xenograft magnetic nanoparticle iron oxide BCL2 BIRC5/survivin oral cancer aptamers cancer nanoparticles STAT6 polyaspartamide pegylation polyamine polyplexes asthma 3-03936-200-3 3-03936-201-1 Angela Barba, Anna edt Lamberti, Gaetano oth Angela Barba, Anna oth |
language |
English |
format |
eBook |
author2 |
Angela Barba, Anna Lamberti, Gaetano Angela Barba, Anna |
author_facet |
Angela Barba, Anna Lamberti, Gaetano Angela Barba, Anna |
author2_variant |
g l gl b a a ba baa |
author2_role |
HerausgeberIn Sonstige Sonstige |
title |
Drug Delivery of siRNA Therapeutics |
spellingShingle |
Drug Delivery of siRNA Therapeutics |
title_full |
Drug Delivery of siRNA Therapeutics |
title_fullStr |
Drug Delivery of siRNA Therapeutics |
title_full_unstemmed |
Drug Delivery of siRNA Therapeutics |
title_auth |
Drug Delivery of siRNA Therapeutics |
title_new |
Drug Delivery of siRNA Therapeutics |
title_sort |
drug delivery of sirna therapeutics |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
physical |
1 electronic resource (288 p.) |
isbn |
3-03936-200-3 3-03936-201-1 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT lambertigaetano drugdeliveryofsirnatherapeutics AT angelabarbaanna drugdeliveryofsirnatherapeutics |
status_str |
n |
ids_txt_mv |
(CKB)5400000000042842 (oapen)https://directory.doabooks.org/handle/20.500.12854/68603 (EXLCZ)995400000000042842 |
carrierType_str_mv |
cr |
is_hierarchy_title |
Drug Delivery of siRNA Therapeutics |
author2_original_writing_str_mv |
noLinkedField noLinkedField noLinkedField |
_version_ |
1796652211957137409 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>04041nam-a2201093z--4500</leader><controlfield tag="001">993545996204498</controlfield><controlfield tag="005">20231214133211.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202105s2020 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)5400000000042842</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/68603</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)995400000000042842</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Lamberti, Gaetano</subfield><subfield code="4">edt</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Drug Delivery of siRNA Therapeutics</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="a">Basel, Switzerland</subfield><subfield code="b">MDPI - Multidisciplinary Digital Publishing Institute</subfield><subfield code="c">2020</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (288 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The new frontier of pharmaceutical sciences is gene therapy, which is the use of molecules able to interact directly with the expression of the genetic material of the patient as well as of the disease-causing guest (bacteria, virus, parasites, and tumor cells). Among the molecules of interest for gene therapy, a relevant role is played by small interfering RNA (siRNA) molecules able to interfere with the expression of genes of interest for some diseases. However, siRNA molecules, even if they are powerful as drugs, are difficult to deliver since they are sensitive to enzymes present in plasma and they are large and negatively charged, so are difficult to administer into the cell nuclei, since the cell walls are scarcely permeable to large molecules and are also negatively charged. Therefore, the focus of research on siRNA-based therapies is their delivery, which can be performed by chemical modification, association with aptamers or polycations, or embedding them into properly designed liposomes. This book is centered on the more recent development in siRNA delivery techniques toward the clinical applications of this potent class of drugs.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Medicine</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">oligonucleotide delivery</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">light-activated release</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">intracellular release</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">liposome</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">indocyanine green</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">drug co-delivery</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">methotrexate</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">siRNA</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">antitumor effect</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mixed micelles</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">targeted delivery system</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cationic liposome</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">folate</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">folate receptor</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cationic cholesterol derivative</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">siRNA delivery</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">gene knockdown</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">tumor-targeting</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">VEGFA</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">VEGFR1</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">endoglin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">peptide</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">angiogenesis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">gene silencing</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">migration</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">proliferation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">endothelial cells</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">RNAi therapeutics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">amphiphilic dendrons</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">PAMAM dendrimers</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">self-assembling</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">nanovectors</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">covalent dendrimers</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">NABDs</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">liposomes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">clinical trials</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">drug delivery</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">nanoparticle</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">carbonate apatite</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">ERBB2</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">AKT</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">breast cancer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">ovarian cancer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">polymer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">lipid</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">delivery</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">poly(ethylene) imine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">PEI</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">RNA</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">tyrosine-modification</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">tumor xenograft</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">magnetic nanoparticle</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">iron oxide</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">BCL2</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">BIRC5/survivin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">oral cancer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">aptamers</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cancer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">nanoparticles</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">STAT6</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">polyaspartamide</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">pegylation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">polyamine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">polyplexes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">asthma</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-03936-200-3</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-03936-201-1</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Angela Barba, Anna</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lamberti, Gaetano</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Angela Barba, Anna</subfield><subfield code="4">oth</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:46:32 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2022-04-04 09:22:53 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338061420004498&Force_direct=true</subfield><subfield code="Z">5338061420004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338061420004498</subfield></datafield></record></collection> |