Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues

The cardiac function relies on an intricate molecular and cellular three-dimensional (3d) architecture of a complex, dense and co-dependent cellular network. Structural alterations of the cardiac structure can affect its essential function and lead to severe dysfunction of the organ. Cardiovascular...

Full description

Saved in:
Bibliographic Details
:
Year of Publication:2022
Language:English
Tags: Add Tag
No Tags, Be the first to tag this record!
id 993545973104498
ctrlnum (CKB)5400000000045256
(oapen)https://directory.doabooks.org/handle/20.500.12854/79565
(EXLCZ)995400000000045256
collection bib_alma
record_format marc
spelling Reichardt, Marius auth
Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
Universitätsverlag Göttingen 2022
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
The cardiac function relies on an intricate molecular and cellular three-dimensional (3d) architecture of a complex, dense and co-dependent cellular network. Structural alterations of the cardiac structure can affect its essential function and lead to severe dysfunction of the organ. Cardiovascular diseases are the main cause of death worldwide with a rising incidence. However, it is not possible to give a generalized answer how the heart is formed. Up to now, cardiac structure as well as physiologic and disease-related tissue alterations of the tissue are mainly investigated by established 2d imaging methods such as optical microscopy or electron microscopy. This work presents a multiscale and multimodal X-ray imaging approach, which allows to probe the heart structure from the scale of entire intact murine hearts to the molecular organisation of the sarcomer structure. While the molecular structure of the actomyosin complex is probed by scanning X-ray diffraction, the 3d arrangement of the cellular network is investigated by propagation-based X-ray phase-contrast tomography. In this context, the concept of 3d virtual histology of cardiac tissue by X-ray phase-contrast tomography using laboratory sources as well as highly coherent synchrotron radiation is being further developed.
English
Physics bicssc
X-ray
cardiac cells
cardiac tissues
3-86395-536-6
language English
format eBook
author Reichardt, Marius
spellingShingle Reichardt, Marius
Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
author_facet Reichardt, Marius
author_variant m r mr
author_sort Reichardt, Marius
title Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
title_full Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
title_fullStr Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
title_full_unstemmed Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
title_auth Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
title_new Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
title_sort multiscale x-ray structural analysis of cardiac cells and tissues
publisher Universitätsverlag Göttingen
publishDate 2022
isbn 3-86395-536-6
illustrated Not Illustrated
work_keys_str_mv AT reichardtmarius multiscalexraystructuralanalysisofcardiaccellsandtissues
status_str n
ids_txt_mv (CKB)5400000000045256
(oapen)https://directory.doabooks.org/handle/20.500.12854/79565
(EXLCZ)995400000000045256
carrierType_str_mv cr
is_hierarchy_title Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
_version_ 1787548726766600192
fullrecord <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02179nam-a2200289z--4500</leader><controlfield tag="001">993545973104498</controlfield><controlfield tag="005">20231214132921.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202203s2022 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)5400000000045256</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/79565</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)995400000000045256</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Reichardt, Marius</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Universitätsverlag Göttingen</subfield><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The cardiac function relies on an intricate molecular and cellular three-dimensional (3d) architecture of a complex, dense and co-dependent cellular network. Structural alterations of the cardiac structure can affect its essential function and lead to severe dysfunction of the organ. Cardiovascular diseases are the main cause of death worldwide with a rising incidence. However, it is not possible to give a generalized answer how the heart is formed. Up to now, cardiac structure as well as physiologic and disease-related tissue alterations of the tissue are mainly investigated by established 2d imaging methods such as optical microscopy or electron microscopy. This work presents a multiscale and multimodal X-ray imaging approach, which allows to probe the heart structure from the scale of entire intact murine hearts to the molecular organisation of the sarcomer structure. While the molecular structure of the actomyosin complex is probed by scanning X-ray diffraction, the 3d arrangement of the cellular network is investigated by propagation-based X-ray phase-contrast tomography. In this context, the concept of 3d virtual histology of cardiac tissue by X-ray phase-contrast tomography using laboratory sources as well as highly coherent synchrotron radiation is being further developed.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Physics</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">X-ray</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cardiac cells</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cardiac tissues</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-86395-536-6</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:35:39 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2022-04-04 09:22:53 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&amp;portfolio_pid=5338084490004498&amp;Force_direct=true</subfield><subfield code="Z">5338084490004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338084490004498</subfield></datafield></record></collection>