Bioprocess Monitoring and Control

Process monitoring and control are fundamental to all processes; this holds especially for bioprocesses, due to their complex nature. Usually, bioprocesses deal with living cells, which have their own regulatory systems. It helps to adjust the cell to its environmental condition. This must not be th...

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Year of Publication:2020
Language:English
Physical Description:1 electronic resource (234 p.)
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100 1 |a Hitzmann, Bernd  |4 edt 
245 1 0 |a Bioprocess Monitoring and Control 
260 |a Basel, Switzerland  |b MDPI - Multidisciplinary Digital Publishing Institute  |c 2020 
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520 |a Process monitoring and control are fundamental to all processes; this holds especially for bioprocesses, due to their complex nature. Usually, bioprocesses deal with living cells, which have their own regulatory systems. It helps to adjust the cell to its environmental condition. This must not be the optimal condition that the cell needs to produce whatever is desired. Therefore, a close monitoring of the cell and its environment is essential to provide optimal conditions for production. Without measurement, no information of the current process state is obtained. In this book, methods and techniques are provided for the monitoring and control of bioprocesses. From new developments for sensors, the application of spectroscopy and modelling approaches, the estimation and observer implementation for ethanol production and the development and scale-up of various bioprocesses and their closed loop control information are presented. The processes discussed here are very diverse. The major applications are cultivation processes, where microorganisms were grown, but also an incubation process of bird’s eggs, as well as an indoor climate control for humans, will be discussed. Altogether, in 12 chapters, nine original research papers and three reviews are presented. 
546 |a English 
650 7 |a Research & information: general  |2 bicssc 
650 7 |a Biology, life sciences  |2 bicssc 
653 |a bioenvironmental control 
653 |a model-predictive controller 
653 |a zonal controlling 
653 |a dynamic modelling 
653 |a flotation 
653 |a bioleaching 
653 |a frother 
653 |a mixed culture 
653 |a machine learning 
653 |a Raman spectroscopy 
653 |a downstream processing 
653 |a chromatography 
653 |a flow cell 
653 |a extended Kalman filter 
653 |a biotechnological processes 
653 |a bioreactor control 
653 |a specific growth rate control 
653 |a batch-to-batch reproducibility 
653 |a thermal sensation 
653 |a thermal comfort 
653 |a machine-learning 
653 |a prediction 
653 |a adaptive controlling 
653 |a thermal growth curve 
653 |a temperature modeling 
653 |a thermoregulation 
653 |a monitoring and control 
653 |a bioprocess engineering 
653 |a calorimetry 
653 |a biocontrol agent 
653 |a Bacillus subtilis natto 
653 |a isolation 
653 |a molecular identification 
653 |a medium optimization 
653 |a antimicrobial activity 
653 |a bactericides 
653 |a spectral analyses 
653 |a biological selenate reduction 
653 |a electron donor competition 
653 |a nitrate 
653 |a perchlorate 
653 |a sequencing batch 
653 |a Pseudomonas 
653 |a siderophores 
653 |a antagonism 
653 |a batch fermentation 
653 |a exponential fed-batch fermentation 
653 |a bio-friendly formulations 
653 |a biocontrol 
653 |a nonlinear state estimation 
653 |a geometric observer 
653 |a bioreactor 
653 |a continuous system 
653 |a model-based sensor 
653 |a well-defined macromolecules 
653 |a sequence-defined macromolecules 
653 |a sequence-defined polymers 
653 |a conjugated oligomers 
653 |a oligo(arylene ethynylene)s 
653 |a biosensors 
653 |a sensors 
653 |a process monitoring 
653 |a bioprocess monitoring and control 
653 |a signal noise management 
653 |a dielectric spectroscopy 
653 |a PAT 
653 |a microbial bioprocessing 
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