Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment
ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that...
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Di Meo, Sergio edt Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment Physiological and Pathological Role of ROS Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 1 electronic resource (236 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms’ adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging. English Research & information: general bicssc Biology, life sciences bicssc CTCL apoptosis cell viability c-FLIP XIAP artemisinin SH-SY5Y cells hippocampal neurons H2O2 AMPK pathway atherosclerosis sphingomyelin synthase 2 endothelial dysfunction endoplasmic reticulum stress β-catenin insulin resistance cancer cardiovascular disease neurodegenerative disorders exercise mitochondria oxidative stress PGC-1 Nrf2 UCPs ROS light DNA damage evolution D-box cavefish Spalax trimethylamine N-oxide cardiomyocytes cardiotoxicity mitochondrial membrane potential CORM-2 NADPH oxidase AP-1 HO-1 Renal cell carcinoma (RCC) reactive oxygen species (ROS) glutathione (GSH) metabolism cancer therapy clear cell RCC papillary RCC chromophobe RCC sarcopenia reactive oxygen species redox signaling antioxidant supplementation protein aggregation redox proteinopathy peroxiredoxins tumorigenesis ROS scavengers 3-03936-282-8 3-03936-283-6 Venditti, Paola edt Napolitano, Gaetana edt Di Meo, Sergio oth Venditti, Paola oth Napolitano, Gaetana oth |
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English |
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eBook |
author2 |
Venditti, Paola Napolitano, Gaetana Di Meo, Sergio Venditti, Paola Napolitano, Gaetana |
author_facet |
Venditti, Paola Napolitano, Gaetana Di Meo, Sergio Venditti, Paola Napolitano, Gaetana |
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m s d ms msd p v pv g n gn |
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HerausgeberIn HerausgeberIn Sonstige Sonstige Sonstige |
title |
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
spellingShingle |
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
title_full |
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
title_fullStr |
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
title_full_unstemmed |
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
title_auth |
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
title_alt |
Physiological and Pathological Role of ROS |
title_new |
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
title_sort |
physiological and pathological role of ros: benefits and limitations of antioxidant treatment |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
physical |
1 electronic resource (236 p.) |
isbn |
3-03936-282-8 3-03936-283-6 |
illustrated |
Not Illustrated |
work_keys_str_mv |
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status_str |
n |
ids_txt_mv |
(CKB)5400000000043418 (oapen)https://directory.doabooks.org/handle/20.500.12854/68973 (EXLCZ)995400000000043418 |
carrierType_str_mv |
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Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
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