Protein-Ligand Interactions: Target Identification and Drug Discovery
Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of th...
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| Year of Publication: | 2021 |
| Language: | English |
| Physical Description: | 1 electronic resource (184 p.) |
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(CKB)5400000000042854 (oapen)https://directory.doabooks.org/handle/20.500.12854/76609 (EXLCZ)995400000000042854 |
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Altieri, Fabio edt Protein-Ligand Interactions: Target Identification and Drug Discovery Protein—Ligand Interactions Protein-Ligand Interactions Protein–Ligand Interactions Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (184 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials. English Research & information: general bicssc Chemistry bicssc serum half-life extension fatty acid conjugation FcRn-mediated recycling serum albumin translocator protein (TSPO) CoCl2 mitochondrial membrane potential reactive oxygen species (ROS) cell viability cell death lung cancer cell line acetylcholinesterase amyloid beta aggregation neuroprotection molecular docking multi-target drug structure–activity relationship brassicasterol phytosterols HSV Mycobacterium tuberculosis HSV-1 DNA polymerase HSV-1 TK human CDK2 ACE UDP-galactopyranose mutase heat shock protein 70 Hsp70 piperine fluorescence spectroscopy molecular dynamics molecular biophysics GADD45β MKK7 multiple myeloma protein-ligand interaction STD-NMR sigma receptors sigma ligands cancer SIGMAR1 PGRMC1 TMEM97 NCI60 COMPARE analysis membrane lipid-protein interaction lipid signalling kinase regulation phosphatidylinositols molecular docking simulation target identification small-molecule derivatives of salicylanilide drug discovery drug development thyroid diseases endocrine disruptor compound human umbilical artery vascular homeostasis 3-0365-1050-8 3-0365-1051-6 Altieri, Fabio oth |
| language |
English |
| format |
eBook |
| author2 |
Altieri, Fabio |
| author_facet |
Altieri, Fabio |
| author2_variant |
f a fa |
| author2_role |
Sonstige |
| title |
Protein-Ligand Interactions: Target Identification and Drug Discovery |
| spellingShingle |
Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_full |
Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_fullStr |
Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_full_unstemmed |
Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_auth |
Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_alt |
Protein—Ligand Interactions Protein-Ligand Interactions Protein–Ligand Interactions |
| title_new |
Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_sort |
protein-ligand interactions: target identification and drug discovery |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2021 |
| physical |
1 electronic resource (184 p.) |
| isbn |
3-0365-1050-8 3-0365-1051-6 |
| illustrated |
Not Illustrated |
| work_keys_str_mv |
AT altierifabio proteinligandinteractionstargetidentificationanddrugdiscovery AT altierifabio proteinligandinteractions |
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n |
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(CKB)5400000000042854 (oapen)https://directory.doabooks.org/handle/20.500.12854/76609 (EXLCZ)995400000000042854 |
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cr |
| is_hierarchy_title |
Protein-Ligand Interactions: Target Identification and Drug Discovery |
| author2_original_writing_str_mv |
noLinkedField |
| _version_ |
1787548858577846272 |
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