The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder
Proteins represent one of the most abundant classes of biological macromolecules and play crucial roles in a vast array of physiological and pathological processes. The knowledge of the 3D structure of a protein, as well as the possible conformational transitions occurring upon interaction with dive...
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Leone, Marilisa edt The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder Conformational Universe of Proteins and Peptides Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (230 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Proteins represent one of the most abundant classes of biological macromolecules and play crucial roles in a vast array of physiological and pathological processes. The knowledge of the 3D structure of a protein, as well as the possible conformational transitions occurring upon interaction with diverse ligands, are essential to fully comprehend its biological function.In addition to globular, well-folded proteins, over the past few years, intrinsically disordered proteins (IDPs) have received a lot of attention. IDPs are usually aggregation-prone and may form toxic amyloid fibers and oligomers associated with several human pathologies. Peptides are smaller in size than proteins but similarly represent key elements of cells. A few peptides are able to work as tumor markers and find applications in the diagnostic and therapeutic fields. The conformational analysis of bioactive peptides is important to design novel potential drugs acting as selective modulators of specific receptors or enzymes. Nevertheless, synthetic peptides reproducing different protein fragments have frequently been implemented as model systems in folding studies relying on structural investigations in water and/or other environments.This book contains contributions (seven original research articles and five reviews published in the journal Molecules) on the above-described topics and, in detail, it includes structural studies on globular folded proteins, IDPs and bioactive peptides. These works were conducted usingdifferent experimental methods. English Research & information: general bicssc mass spectrometric epitope mapping gas phase immune complex dissociation apparent gas phase dissociation constants apparent gas phase activation energies ITEM-TWO native mass spectrometry TRIOBP cancer deafness hearing loss mental illness schizophrenia actin cytoskeleton disordered structure protein aggregation solid-state NMR ELDOR-detected NMR ATP hydrolysis ATP analogues DnaB helicase ABC transporter biopesticides antifungal activity insecticidal activity mechanism of action transgenic crops protein folding NMR High Hydrostatic Pressure ACE2 viral spike receptor-binding domain SARS-CoV-2 transmission bioinformatics IDP 1 binding 2 molecular dynamics 3 MELD×MD 4 advanced sampling 5 p53 6 MDM2 7 NAD(P)H-dependent oxidoreductase zinc-containing alcohol dehydrogenase cofactor binding and release interdomain cleft dynamics molecular dynamics simulations denatured state ensemble protein coil library peptides intrinsically disordered proteins ion-pairing interaction side-chain length charged amino acids β-hairpin peptide Friedman's test backbone atom coordinate variances and uncertainties superimposition nanobody protein structure immunoglobulin domain 3-0365-2352-9 3-0365-2351-0 Leone, Marilisa oth |
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English |
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eBook |
author2 |
Leone, Marilisa |
author_facet |
Leone, Marilisa |
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m l ml |
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Sonstige |
title |
The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
spellingShingle |
The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
title_full |
The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
title_fullStr |
The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
title_full_unstemmed |
The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
title_auth |
The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
title_alt |
Conformational Universe of Proteins and Peptides |
title_new |
The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
title_sort |
the conformational universe of proteins and peptides: tales of order and disorder |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
physical |
1 electronic resource (230 p.) |
isbn |
3-0365-2352-9 3-0365-2351-0 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT leonemarilisa theconformationaluniverseofproteinsandpeptidestalesoforderanddisorder AT leonemarilisa conformationaluniverseofproteinsandpeptides |
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(CKB)5400000000042180 (oapen)https://directory.doabooks.org/handle/20.500.12854/76965 (EXLCZ)995400000000042180 |
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The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder |
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1796651961033949184 |
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