Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients
Research and advances in the treatment of Multiple Sclerosis (MS) is a story of growing success. Great progress has been made in identifying the molecular mechanisms that can be utilized to develop highly efficacious treatments for MS patients. Since the middle of the last century, when studies usin...
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Stefan Rommer, Paulus edt Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients Multiple Sclerosis â From Bench to Bedside Multiple Sclerosis – From Bench to Bedside Frontiers Media SA 2020 1 electronic resource (253 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Research and advances in the treatment of Multiple Sclerosis (MS) is a story of growing success. Great progress has been made in identifying the molecular mechanisms that can be utilized to develop highly efficacious treatments for MS patients. Since the middle of the last century, when studies using an inflammatory autoimmune model of MS i.e. experimental autoimmune encephalitis (EAE) were initiated, research on MS has since led to an enormous growth of knowledge. The limitations arising from these animal models have been partially compensated by insights generated from histopathological, immunological, genetic, imaging and clinical studies of MS. The importance of T cells and, recently of B cells, in MS has been elucidated and the significance of CNS resident cells, particularly in the progressive course of MS has been highlighted. The importance of environmental factors and genetic predisposition have also been recognized and the interaction between th e individual and its environment seems to play key roles in the pathogenesis of this disease. However, definite causative agent(s) or single gene(s) involved in MS still remain unidentified. A deeper understanding of the immunological pathways involved goes hand in hand with further improving therapy for MS. Focal inflammation in MS, caused by de novo CNS infiltration, can be prevented effectively using peripherally-acting drugs. However, diffuse CNS intrinsic inflammation and neurodegeneration are not targeted by the current arsenal of therapeutics and patients with progressive disease courses remain difficult to treat. Generating insights into pathophysiological processes and the clinical translation of this knowledge have been a formula of success for treating inflammatory diseases. The future will show whether this will hold true for CNS-trapped inflammation and neurodegeneration and whether the ultimate goal – truly curing MS – will be possible. English Medicine bicssc Immunology bicssc Multiple Sclerosis Multiple Sclerois and Neuroimmunology Multiple sclerosis - drug therapy Multiple sclerosis - epidemiology Multiple sclerosis - etiology 2-88963-566-X Weber, Martin S. edt Illes, Zsolt edt Zettl, Uwe K. edt Stefan Rommer, Paulus oth Weber, Martin S. oth Illes, Zsolt oth Zettl, Uwe K. oth |
language |
English |
format |
eBook |
author2 |
Weber, Martin S. Illes, Zsolt Zettl, Uwe K. Stefan Rommer, Paulus Weber, Martin S. Illes, Zsolt Zettl, Uwe K. |
author_facet |
Weber, Martin S. Illes, Zsolt Zettl, Uwe K. Stefan Rommer, Paulus Weber, Martin S. Illes, Zsolt Zettl, Uwe K. |
author2_variant |
r p s rp rps m s w ms msw z i zi u k z uk ukz |
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HerausgeberIn HerausgeberIn HerausgeberIn Sonstige Sonstige Sonstige Sonstige |
title |
Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients |
spellingShingle |
Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients |
title_full |
Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients |
title_fullStr |
Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients |
title_full_unstemmed |
Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients |
title_auth |
Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients |
title_alt |
Multiple Sclerosis â From Bench to Bedside Multiple Sclerosis – From Bench to Bedside |
title_new |
Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients |
title_sort |
multiple sclerosis – from bench to bedside: currents insights into pathophysiological concepts and their potential impact on patients |
publisher |
Frontiers Media SA |
publishDate |
2020 |
physical |
1 electronic resource (253 p.) |
isbn |
2-88963-566-X |
illustrated |
Not Illustrated |
work_keys_str_mv |
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Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients |
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