Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations
Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they...
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Year of Publication: | 2021 |
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Physical Description: | 1 electronic resource (248 p.) |
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Ciarimboli, Giuliano edt Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (248 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field. English Medicine bicssc transporters endogenous metabolism functional subgroups SLC22 remote sensing and signaling drug transporters gut microbiome chronic kidney disease solute carrier 22 (SLC22) Remote Sensing and Signaling Theory interorgan communication organic anion transporter organic cation transporter SLC22A15 SLC22A16 SLC22A18 kidney Malpighian tubule TCGA human pathology atlas gene ontology organic cations transport kidneys regulation Nuclear receptor renal excretion bile acids organic cation transporters drug disposition genetic polymorphisms drug-induced kidney injury nephrotoxicity RA Tofacitinib Baricitinib MATE1 solute carrier (SLC) family OCT1 SLC22A1 species differences drugs pesticides cisplatin nephrotoxicity PPAR-alpha organic transporters serotonin transporter plasma membrane monoamine transporter ketamine isoflurane serotonin clearance antidepressant-like activity chronoamperometry tail suspension test forced swim test hepatotoxicity solute carrier pulmonary drug delivery SLC22A1-5 lung epithelium drug uptake β2-agonists chronic lung diseases anticholinergics trospium OCT MATE drug excretion drug transport 3-0365-0562-8 3-0365-0563-6 Ciarimboli, Giuliano oth |
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English |
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author2 |
Ciarimboli, Giuliano |
author_facet |
Ciarimboli, Giuliano |
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g c gc |
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Sonstige |
title |
Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
spellingShingle |
Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
title_full |
Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
title_fullStr |
Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
title_full_unstemmed |
Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
title_auth |
Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
title_new |
Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
title_sort |
physiology, biochemistry, and pharmacology of transporters for organic cations |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
physical |
1 electronic resource (248 p.) |
isbn |
3-0365-0562-8 3-0365-0563-6 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT ciarimboligiuliano physiologybiochemistryandpharmacologyoftransportersfororganiccations |
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(CKB)5400000000042428 (oapen)https://directory.doabooks.org/handle/20.500.12854/76476 (EXLCZ)995400000000042428 |
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Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
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1787548496135454720 |
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