Paediatric Formulation: Design and Development

Paediatric Formulation: Design and Development

The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration;...

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HerausgeberIn:
Lopalco, Antonio
Sonstige:
Denora, Nunzio
Lopalco, Antonio
Year of Publication:2021
Language:English
Physical Description:1 electronic resource (205 p.)
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(oapen)https://directory.doabooks.org/handle/20.500.12854/76438
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spelling Denora, Nunzio edt
Paediatric Formulation: Design and Development
Paediatric Formulation
Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
1 electronic resource (205 p.)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
English
Medicine bicssc
dasatinib
Duchenne muscular dystrophy
cyclodextrin inclusion complex
phase solubility studies
paediatric age
liquid formulation
tumorspheres
retinoblastoma
topotecan
penetration
confocal microscopy
poorly water soluble drug
solubility enhancement
grinding
spray congealing
neglected tropical diseases
polymorph
Norvir®
ritonavir
poorly soluble compound
pediatric
palatability assessment
bioavailability
flavor profile
Interleukin-1
anakinra
canakinumab
innovative biotechnologies
autoinflammatory disease
Kawasaki disease
systemic juvenile idiopathic arthritis
personalized medicine
child
pediatrics
neonates
formulation
product development
formulation development
oral
parenteral
topical
inhaled
intra nasal
biopharmaceutics
administration
excipient
NICU
device
medication error
dosage form
modified release
drug delivery
paediatric formulation development
paediatric dosage forms
chronic myeloid leukemia
tyrosine kinase inhibitors
pediatric age
imatinib
nilotinb
ponatinib
Orodispersible formulation
pyrazinamide
pediatric drug delivery
tuberculosis
design of experiments
children
edible films
development
design
paediatric
age-related
palatable
taste-masking
acceptable
3-0365-0740-X
3-0365-0741-8
Lopalco, Antonio edt
Denora, Nunzio oth
Lopalco, Antonio oth
language English
format eBook
author2 Lopalco, Antonio
Denora, Nunzio
Lopalco, Antonio
author_facet Lopalco, Antonio
Denora, Nunzio
Lopalco, Antonio
author2_variant n d nd
a l al
author2_role HerausgeberIn
Sonstige
Sonstige
title Paediatric Formulation: Design and Development
spellingShingle Paediatric Formulation: Design and Development
title_full Paediatric Formulation: Design and Development
title_fullStr Paediatric Formulation: Design and Development
title_full_unstemmed Paediatric Formulation: Design and Development
title_auth Paediatric Formulation: Design and Development
title_alt Paediatric Formulation
title_new Paediatric Formulation: Design and Development
title_sort paediatric formulation: design and development
publisher MDPI - Multidisciplinary Digital Publishing Institute
publishDate 2021
physical 1 electronic resource (205 p.)
isbn 3-0365-0740-X
3-0365-0741-8
illustrated Not Illustrated
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