Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0
This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in ins...
Saved in:
HerausgeberIn: | |
---|---|
Sonstige: | |
Year of Publication: | 2021 |
Language: | English |
Physical Description: | 1 electronic resource (286 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993545869304498 |
---|---|
ctrlnum |
(CKB)5400000000045751 (oapen)https://directory.doabooks.org/handle/20.500.12854/76512 (EXLCZ)995400000000045751 |
collection |
bib_alma |
record_format |
marc |
spelling |
Dansette, Patrick M. edt Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 Cytochromes P450 Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (286 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor. English Research & information: general bicssc Antibiotics Bacillus biosynthetic gene clusters comparative analysis cytochrome P450 monooxygenase Mycobacterium P450 diversity percentage P450 profiling secondary metabolites NADPH-cytochrome P450 reductase (CPR) microsomal cytochrome P450 (CYP) Cytochrome b5 (CYB5) protein dynamics electron-transfer (ET) protein–protein interaction cytochromes P450 CYP3A4 active site access channels cavities boundaries minimal cost paths CYP139A1 genome data mining host metabolism Mycobacterium tuberculosis polyketides tuberculosis cryptococcus cryptococcus neoformans CYP51 fungal pathogens genome data-mining human pathogens CYP diversity analysis tremellomycetes trichosporon mechanism-based inhibitor crystal structure CYP4 genes genetic polymorphisms 20-HETE fatty acid arachidonic acid SNPs molecular functionality metabolism lamellar ichthyosis Bietti’s crystalline dystrophy cytochrome P450 isoform membrane protein protein-membrane interactions enzyme substrate specificity mutagenesis molecular dynamics simulation Sogatella furcifera sulfoxaflor transcriptome RNA interference CYP2C8 polymorphisms reactive oxygen species paclitaxel cytochrome P450 reductase electron transfer extracellular vesicles exosomes extrahepatic tissues plasma circulatory CYPs CYP450 drug metabolism precision Cardio-Oncology precision medicine systems medicine cytochromes P450 monooxygenases Cyanobacteria gene-cluster diversity percentage mathematical formula phylogenetic analysis Streptomyces cytochrome P450 monooxygenases terpenes P450 blooming non-ribosomal peptides cytochrome P450 monooxygenenases CYP128A1 Mycobacterium tuberculosis H37Rv molecular dynamic simulations azole drugs menaquinone 3-0365-0256-4 3-0365-0257-2 Werck, Danièle edt Dansette, Patrick M. oth Werck, Danièle oth |
language |
English |
format |
eBook |
author2 |
Werck, Danièle Dansette, Patrick M. Werck, Danièle |
author_facet |
Werck, Danièle Dansette, Patrick M. Werck, Danièle |
author2_variant |
p m d pm pmd d w dw |
author2_role |
HerausgeberIn Sonstige Sonstige |
title |
Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
spellingShingle |
Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
title_full |
Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
title_fullStr |
Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
title_full_unstemmed |
Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
title_auth |
Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
title_alt |
Cytochromes P450 |
title_new |
Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
title_sort |
cytochromes p450: drug metabolism, bioactivation and biodiversity 2.0 |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
physical |
1 electronic resource (286 p.) |
isbn |
3-0365-0256-4 3-0365-0257-2 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT dansettepatrickm cytochromesp450drugmetabolismbioactivationandbiodiversity20 AT werckdaniele cytochromesp450drugmetabolismbioactivationandbiodiversity20 AT dansettepatrickm cytochromesp450 AT werckdaniele cytochromesp450 |
status_str |
n |
ids_txt_mv |
(CKB)5400000000045751 (oapen)https://directory.doabooks.org/handle/20.500.12854/76512 (EXLCZ)995400000000045751 |
carrierType_str_mv |
cr |
is_hierarchy_title |
Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
author2_original_writing_str_mv |
noLinkedField noLinkedField noLinkedField |
_version_ |
1787548726799106049 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>05702nam-a2201405z--4500</leader><controlfield tag="001">993545869304498</controlfield><controlfield tag="005">20231214132838.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202201s2021 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)5400000000045751</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/76512</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)995400000000045751</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Dansette, Patrick M.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0</subfield></datafield><datafield tag="246" ind1=" " ind2=" "><subfield code="a">Cytochromes P450</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="a">Basel, Switzerland</subfield><subfield code="b">MDPI - Multidisciplinary Digital Publishing Institute</subfield><subfield code="c">2021</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (286 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Research & information: general</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Antibiotics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Bacillus</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">biosynthetic gene clusters</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">comparative analysis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytochrome P450 monooxygenase</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Mycobacterium</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">P450 diversity percentage</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">P450 profiling</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">secondary metabolites</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">NADPH-cytochrome P450 reductase (CPR)</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">microsomal cytochrome P450 (CYP)</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Cytochrome b5 (CYB5)</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">protein dynamics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">electron-transfer (ET)</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">protein–protein interaction</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytochromes P450</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CYP3A4</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">active site access channels</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cavities boundaries</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">minimal cost paths</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CYP139A1</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">genome data mining</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">host metabolism</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Mycobacterium tuberculosis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">polyketides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">tuberculosis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cryptococcus</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cryptococcus neoformans</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CYP51</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">fungal pathogens</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">genome data-mining</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">human pathogens</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CYP diversity analysis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">tremellomycetes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">trichosporon</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mechanism-based inhibitor</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">crystal structure</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CYP4 genes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">genetic polymorphisms</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">20-HETE</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">fatty acid</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">arachidonic acid</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">SNPs</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">molecular functionality</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">metabolism</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">lamellar ichthyosis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Bietti’s crystalline dystrophy</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytochrome P450</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">isoform</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">membrane protein</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">protein-membrane interactions</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">enzyme substrate specificity</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mutagenesis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">molecular dynamics simulation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Sogatella furcifera</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">sulfoxaflor</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">transcriptome</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">RNA interference</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CYP2C8</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">polymorphisms</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">reactive oxygen species</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">paclitaxel</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytochrome P450 reductase</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">electron transfer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">extracellular vesicles</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">exosomes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">extrahepatic tissues</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">plasma</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">circulatory CYPs</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CYP450</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">drug metabolism</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">precision Cardio-Oncology</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">precision medicine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">systems medicine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytochromes P450 monooxygenases</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Cyanobacteria</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">gene-cluster diversity percentage</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mathematical formula</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">phylogenetic analysis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Streptomyces</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytochrome P450 monooxygenases</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">terpenes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">P450 blooming</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">non-ribosomal peptides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytochrome P450 monooxygenenases</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CYP128A1</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Mycobacterium tuberculosis H37Rv</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">molecular dynamic simulations</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">azole drugs</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">menaquinone</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-0365-0256-4</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-0365-0257-2</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Werck, Danièle</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dansette, Patrick M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Werck, Danièle</subfield><subfield code="4">oth</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:33:33 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2022-04-04 09:22:53 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338073310004498&Force_direct=true</subfield><subfield code="Z">5338073310004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338073310004498</subfield></datafield></record></collection> |