Drug Absorption Studies: In Situ, In Vitro and In Silico Models
This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorpt...
Saved in:
| Sonstige: | |
|---|---|
| Year of Publication: | 2021 |
| Language: | English |
| Physical Description: | 1 electronic resource (171 p.) |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
993545822804498 |
|---|---|
| ctrlnum |
(CKB)5400000000044639 (oapen)https://directory.doabooks.org/handle/20.500.12854/77071 (EXLCZ)995400000000044639 |
| collection |
bib_alma |
| record_format |
marc |
| spelling |
Song, Im-Sook edt Drug Absorption Studies: In Situ, In Vitro and In Silico Models Drug Absorption Studies Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (171 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs. English Medicine bicssc Pharmaceutical industries bicssc rebamipide nanocrystals oral mucositis hydrogel endocytosis enoxaparin lipid–polymer hybrid nanoparticles oral intestinal absorption naftidrofuryl oxalate solubility permeability dissolution profiles pharmaceutical availability BCS drug classification non-sink condition solubility–permeability interplay unstirred water layer poorly soluble drugs solubilizer additive phenylketonuria l-phenylalanine ammonia-lyase enzyme kinetics catabolism disorder biomedical drug P-glycoprotein breast cancer resistance protein LY335979 WK-X-34 in vivo–in vitro correlation lipolysis-permeation lipid-based drug delivery system PermeaPad cinnarizine lipolysis amorphous solid dispersion candesartan Cilexetil PVPK30 pH-modulation spray drying bioavailability nasal administration spray-drying chitosan microsphere meloxicam silymarin D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) liver distribution acetaminophen-induced hepatotoxicity extra virgin olive oil secoiridoids metabolism phenolic compounds intestinal permeability drug-phytochemical interaction hepatic metabolism mixed inhibition quercetin repaglinide 3-0365-2461-4 3-0365-2460-6 Song, Im-Sook oth |
| language |
English |
| format |
eBook |
| author2 |
Song, Im-Sook |
| author_facet |
Song, Im-Sook |
| author2_variant |
i s s iss |
| author2_role |
Sonstige |
| title |
Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| spellingShingle |
Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_full |
Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_fullStr |
Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_full_unstemmed |
Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_auth |
Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_alt |
Drug Absorption Studies |
| title_new |
Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_sort |
drug absorption studies: in situ, in vitro and in silico models |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2021 |
| physical |
1 electronic resource (171 p.) |
| isbn |
3-0365-2461-4 3-0365-2460-6 |
| illustrated |
Not Illustrated |
| work_keys_str_mv |
AT songimsook drugabsorptionstudiesinsituinvitroandinsilicomodels AT songimsook drugabsorptionstudies |
| status_str |
n |
| ids_txt_mv |
(CKB)5400000000044639 (oapen)https://directory.doabooks.org/handle/20.500.12854/77071 (EXLCZ)995400000000044639 |
| carrierType_str_mv |
cr |
| is_hierarchy_title |
Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| author2_original_writing_str_mv |
noLinkedField |
| _version_ |
1787548474241187840 |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03798nam-a2201045z--4500</leader><controlfield tag="001">993545822804498</controlfield><controlfield tag="005">20231214133312.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202201s2021 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)5400000000044639</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/77071</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)995400000000044639</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Song, Im-Sook</subfield><subfield code="4">edt</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Drug Absorption Studies: In Situ, In Vitro and In Silico Models</subfield></datafield><datafield tag="246" ind1=" " ind2=" "><subfield code="a">Drug Absorption Studies</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="a">Basel, Switzerland</subfield><subfield code="b">MDPI - Multidisciplinary Digital Publishing Institute</subfield><subfield code="c">2021</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (171 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Medicine</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmaceutical industries</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">rebamipide</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">nanocrystals</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">oral mucositis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">hydrogel</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">endocytosis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">enoxaparin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">lipid–polymer hybrid nanoparticles</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">oral</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">intestinal absorption</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">naftidrofuryl oxalate</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">solubility</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">permeability</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">dissolution profiles</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">pharmaceutical availability</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">BCS drug classification</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">non-sink condition</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">solubility–permeability interplay</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">unstirred water layer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">poorly soluble drugs</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">solubilizer additive</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">phenylketonuria</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">l-phenylalanine ammonia-lyase</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">enzyme</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">kinetics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">catabolism disorder</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">biomedical drug</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">P-glycoprotein</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">breast cancer resistance protein</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">LY335979</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">WK-X-34</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">in vivo–in vitro correlation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">lipolysis-permeation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">lipid-based drug delivery system</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">PermeaPad</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cinnarizine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">lipolysis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">amorphous solid dispersion</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">candesartan Cilexetil</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">PVPK30</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">pH-modulation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">spray drying</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">bioavailability</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">nasal administration</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">spray-drying</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">chitosan</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">microsphere</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">meloxicam</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">silymarin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">liver distribution</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">acetaminophen-induced hepatotoxicity</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">extra virgin olive oil</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">secoiridoids</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">metabolism</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">phenolic compounds</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">intestinal permeability</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">drug-phytochemical interaction</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">hepatic metabolism</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mixed inhibition</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">quercetin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">repaglinide</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-0365-2461-4</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-0365-2460-6</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Song, Im-Sook</subfield><subfield code="4">oth</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:49:45 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2022-04-04 09:22:53 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338099360004498&Force_direct=true</subfield><subfield code="Z">5338099360004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338099360004498</subfield></datafield></record></collection> |