Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions
There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound horm...
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David Bikle, Daniel edt Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions Frontiers Media SA 2020 1 electronic resource (86 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form. While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment. In this Research Topic, we provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases. English Medicine bicssc Endocrinology bicssc vitamin D binding protein total 25-hydroxyvitamin D free 25-hydroxyvitamin D 1 25-dihydroxyvitamin D bioavailable 25-hydroxyvitamin D 2-88963-578-3 Xie, Zhongjian edt Wang, Xiangbing edt David Bikle, Daniel oth Xie, Zhongjian oth Wang, Xiangbing oth |
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English |
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Xie, Zhongjian Wang, Xiangbing David Bikle, Daniel Xie, Zhongjian Wang, Xiangbing |
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Xie, Zhongjian Wang, Xiangbing David Bikle, Daniel Xie, Zhongjian Wang, Xiangbing |
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HerausgeberIn HerausgeberIn Sonstige Sonstige Sonstige |
title |
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions |
spellingShingle |
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions |
title_full |
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions |
title_fullStr |
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions |
title_full_unstemmed |
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions |
title_auth |
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions |
title_new |
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions |
title_sort |
vitamin d binding protein, total and free vitamin d levels in different physiological and pathophysiological conditions |
publisher |
Frontiers Media SA |
publishDate |
2020 |
physical |
1 electronic resource (86 p.) |
isbn |
2-88963-578-3 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT davidbikledaniel vitamindbindingproteintotalandfreevitamindlevelsindifferentphysiologicalandpathophysiologicalconditions AT xiezhongjian vitamindbindingproteintotalandfreevitamindlevelsindifferentphysiologicalandpathophysiologicalconditions AT wangxiangbing vitamindbindingproteintotalandfreevitamindlevelsindifferentphysiologicalandpathophysiologicalconditions |
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(CKB)5400000000041733 (oapen)https://directory.doabooks.org/handle/20.500.12854/73730 (EXLCZ)995400000000041733 |
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Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions |
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