Purinergic Signaling in Health and Disease
Adenosine 5’-triphosphate (ATP) is one of the most abundant molecule in living cells serving as universal energy “currency.” After slow acceptance of the concept of the release and extracellular action of ATP, purinergic signaling is recognized as a widespread mechanism for cell-to-cell communicatio...
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Boué-Grabot, Eric edt Purinergic Signaling in Health and Disease Frontiers Media SA 2020 1 electronic resource (330 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Adenosine 5’-triphosphate (ATP) is one of the most abundant molecule in living cells serving as universal energy “currency.” After slow acceptance of the concept of the release and extracellular action of ATP, purinergic signaling is recognized as a widespread mechanism for cell-to-cell communication in living organisms. Additionally, the contribution of pyrimidine nucleotides (such as UTP and UDP) and sugar-nucleotides (i.e., UDP-glucose and UDP-galactose) have been more recently discovered. Purinergic signaling plays major physiological roles in mammalian central nervous system (CNS) such as neurotransmission, neuromodulation, communication in glial network and between neurons and glia. Extracellular ATP and its metabolic breakdown is a source of other nucleotides and adenosine providing the versatile basis for complex purinergic signaling through the activation of several families of purinergic receptors. G-protein coupled P1 receptors for adenosine, ionotropic P2X receptors for ATP and G-protein coupled P2Y receptors for ATP and other nucleotides are abundant and widely distributed in central neurons at pre-and post-synapse and in glial cells. Alterations of purinergic signals are associated with major CNS disorders including chronic pain, brain trauma ischemia, epilepsy, neurodegenerative diseases such as Alzheimer disease or Amyotrophic lateral sclerosis associated with neuro-inflammation as well as neuropsychiatric diseases, including depression, anxiety and schizophrenia. English Science: general issues bicssc Neurosciences bicssc purine P2X P2Y adenosine (A(1) A(2A) A(2B)) receptors purinergic signaling CNS CNS—disorder 2-88963-556-2 Blum, David edt Ceruti, Stefania edt Boué-Grabot, Eric oth Blum, David oth Ceruti, Stefania oth |
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English |
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eBook |
author2 |
Blum, David Ceruti, Stefania Boué-Grabot, Eric Blum, David Ceruti, Stefania |
author_facet |
Blum, David Ceruti, Stefania Boué-Grabot, Eric Blum, David Ceruti, Stefania |
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HerausgeberIn HerausgeberIn Sonstige Sonstige Sonstige |
title |
Purinergic Signaling in Health and Disease |
spellingShingle |
Purinergic Signaling in Health and Disease |
title_full |
Purinergic Signaling in Health and Disease |
title_fullStr |
Purinergic Signaling in Health and Disease |
title_full_unstemmed |
Purinergic Signaling in Health and Disease |
title_auth |
Purinergic Signaling in Health and Disease |
title_new |
Purinergic Signaling in Health and Disease |
title_sort |
purinergic signaling in health and disease |
publisher |
Frontiers Media SA |
publishDate |
2020 |
physical |
1 electronic resource (330 p.) |
isbn |
2-88963-556-2 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT bouegraboteric purinergicsignalinginhealthanddisease AT blumdavid purinergicsignalinginhealthanddisease AT cerutistefania purinergicsignalinginhealthanddisease |
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Purinergic Signaling in Health and Disease |
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