The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy
In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the sur...
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| Year of Publication: | 2021 |
| Language: | English |
| Physical Description: | 1 electronic resource (307 p.) |
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(CKB)5400000000042348 (oapen)https://directory.doabooks.org/handle/20.500.12854/76822 (EXLCZ)995400000000042348 |
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Madureira, Patrícia Alexandra Saraiva edt The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (307 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g., macrophages, tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g., oxidative stress, pH, hypoxia) and the implications of this dynamic interaction to tumor radioresistance, chemoresistance, invasion and metastasis. Finally, the importance and relevance of these findings are translated to cancer therapy. English Medicine bicssc hypoxia macrophages colon cancer tumor microenvironment immune cell infiltration prognosis feline mammary carcinoma PD-1 PD-L1 CTLA-4 TNF-α biomarkers immunotherapy cancer histone modification inhibitor KDM5B molecular docking repurposing cancer acidity hyperosmolarity cross-presentation tumour microenvironment syngeneic model prostate cancer radiotherapy preclinical modelling myeloid-derived suppressor cells biomarker stroma cancer-associated fibroblast (CAF) extracellular matrix (ECM) cytokine/chemokine growth factors pro- and anti-tumor immune cells immunomodulatory roles radiotherapy dose fractionation radioresistance radiosensitivity breast cancer S100A10 (p11) tumor growth tumor progression metastasis carcinoma mammary gland triple negative pre-metastatic niche pro-inflammatory cytokines clinical trials evolutionary therapy darwinian evolution cancer cells subpopulations diclofenac koningic acid spheroid 3D co-culture microenvironment resistance myeloid cells cancer development molecular subtypes of pancreatic cancer chemotherapy response pancreatic stellate cells regulatory T cells tumor-associated macrophages myeloid derived suppressor cells glioblastoma (GB) Hypoxia Inducible Factor (HIF) glioma stem cells (GSC) oxidative stress reactive oxygen species plasmin plasminogen S100A10 uPA uPAR PAI-1 PAI-2 cancer stem cells cancer recurrence therapeutic resistance signaling pathways targeted therapy head and neck cancer lung cancer bladder cancer 3-0365-1608-5 3-0365-1607-7 Madureira, Patrícia Alexandra Saraiva oth |
| language |
English |
| format |
eBook |
| author2 |
Madureira, Patrícia Alexandra Saraiva |
| author_facet |
Madureira, Patrícia Alexandra Saraiva |
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p a s m pas pasm |
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Sonstige |
| title |
The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
| spellingShingle |
The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
| title_full |
The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
| title_fullStr |
The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
| title_full_unstemmed |
The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
| title_auth |
The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
| title_new |
The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
| title_sort |
the shaping of cancer by the tumour microenvironment and its relevance for cancer therapy |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2021 |
| physical |
1 electronic resource (307 p.) |
| isbn |
3-0365-1608-5 3-0365-1607-7 |
| illustrated |
Not Illustrated |
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The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
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