Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy
In the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibit...
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Kwok, Hang Fai edt Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (93 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier In the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibition strategies are one of the fastest expanding areas in the field of of drugs that show considerable promise. This Special Issue will focus on the recent advances in the discovery and development of protease inhibitors, covering the synthesis of protease inhibitors, the design of new chemical entities acting as inhibitors of special/particular types of proteases, and their mode of actions (Frolova et al. 2020; Slapak et al. 2020; Künnapuu et al. 2021). In addition, the new applications of these interesting compounds/biomolecules and their limitations have been discussed and described (Wang et al. 2020; Bartošová-Sojková et al. 2021). English Research & information: general bicssc MMP MMP2 MMP9 MMP7 MMP14 matrix metalloproteases PDAC pancreatic cancer Bowman–Birk inhibitor ranacyclin trypsin inhibitor structure–activity relationship synergistic effect Gentamicin matrix metalloproteinase extracellular matrix nuclei cancer apoptosis immune response cysteine protease inhibitor stefin signal peptide parasite phylogenetic analysis diversification protein structure vascular endothelial growth factors (VEGFs) VEGF-A PlGF VEGF-B VEGF-C VEGF-D angiogenesis lymphangiogenesis CCBE1 proteases ADAMTS3 plasmin cathepsin D KLK3 prostate-specific antigen (PSA) thrombin wound healing metastasis proteolytic activation vascular biology lymphedema 3-0365-2575-0 3-0365-2574-2 Shaw, Christopher edt Walker, Brian edt Kwok, Hang Fai oth Shaw, Christopher oth Walker, Brian oth |
language |
English |
format |
eBook |
author2 |
Shaw, Christopher Walker, Brian Kwok, Hang Fai Shaw, Christopher Walker, Brian |
author_facet |
Shaw, Christopher Walker, Brian Kwok, Hang Fai Shaw, Christopher Walker, Brian |
author2_variant |
h f k hf hfk c s cs b w bw |
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HerausgeberIn HerausgeberIn Sonstige Sonstige Sonstige |
title |
Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy |
spellingShingle |
Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy |
title_full |
Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy |
title_fullStr |
Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy |
title_full_unstemmed |
Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy |
title_auth |
Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy |
title_new |
Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy |
title_sort |
proteases—from basic structure to function to drug design as targeted therapy |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
physical |
1 electronic resource (93 p.) |
isbn |
3-0365-2575-0 3-0365-2574-2 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT kwokhangfai proteasesfrombasicstructuretofunctiontodrugdesignastargetedtherapy AT shawchristopher proteasesfrombasicstructuretofunctiontodrugdesignastargetedtherapy AT walkerbrian proteasesfrombasicstructuretofunctiontodrugdesignastargetedtherapy |
status_str |
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(CKB)5400000000042359 (oapen)https://directory.doabooks.org/handle/20.500.12854/77096 (EXLCZ)995400000000042359 |
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Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy |
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_version_ |
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