Arteriogenesis : Molecular Regulation, Pathophysiology and Therapeutics II
Cardiovascular occlusive diseases, such as myocardial infarction or stroke, are still the major cause of morbidity and mortality worldwide and are, particularly during the SARS-CoV-2 pandemic, drastically increasing. Arteriogenesis, which describes the process of natural arterial bypass growth, is...
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Physical Description: | 1 electronic resource (176 p.) |
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Deindl, Elisabeth edt Arteriogenesis Molecular Regulation, Pathophysiology and Therapeutics II Arteriogenesis Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 1 electronic resource (176 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Open access Unrestricted online access star Cardiovascular occlusive diseases, such as myocardial infarction or stroke, are still the major cause of morbidity and mortality worldwide and are, particularly during the SARS-CoV-2 pandemic, drastically increasing. Arteriogenesis, which describes the process of natural arterial bypass growth, is a tissue- and life-saving process, which is given to us by mother nature to compensate for the function of a stenosed coronary or peripheral artery non-invasively. Since our first investigations on the mechanisms of collateral artery growth, more than 20 years ago, a lot of progress has been made, which we aim to make accessible in the current book. We present the available animal models and share information on the used state of the art techniques. We describe how fluid shear stress, the trigger for arteriogenesis, is translated into biochemical signal transduction cascades, and we also highlight the functional role of extracellular RNA and Il10. We address the problematic features of arteriogenesis in patients suffering from diabetes mellitus, and provide an overview of currently available or potentially therapeutic approaches to promote arteriogenesis in patients. We focus on the combination of ultrasound and microbubbles, the permanent occlusion of the internal mammary arteries, and simple exercise training. We believe that we have come much closer to achieving our goal of understanding the mechanisms of arteriogenesis, enabling clinicians to promote collateral artery growth in patients and cure vascular occlusive diseases. English Medicine bicssc 3-03936-435-9 3-03936-436-7 Quax, Paul edt Deindl, Elisabeth oth Quax, Paul oth |
language |
English |
format |
eBook |
author2 |
Quax, Paul Deindl, Elisabeth Quax, Paul |
author_facet |
Quax, Paul Deindl, Elisabeth Quax, Paul |
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e d ed p q pq |
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HerausgeberIn Sonstige Sonstige |
title |
Arteriogenesis Molecular Regulation, Pathophysiology and Therapeutics II |
spellingShingle |
Arteriogenesis Molecular Regulation, Pathophysiology and Therapeutics II |
title_sub |
Molecular Regulation, Pathophysiology and Therapeutics II |
title_full |
Arteriogenesis Molecular Regulation, Pathophysiology and Therapeutics II |
title_fullStr |
Arteriogenesis Molecular Regulation, Pathophysiology and Therapeutics II |
title_full_unstemmed |
Arteriogenesis Molecular Regulation, Pathophysiology and Therapeutics II |
title_auth |
Arteriogenesis Molecular Regulation, Pathophysiology and Therapeutics II |
title_alt |
Arteriogenesis |
title_new |
Arteriogenesis |
title_sort |
arteriogenesis molecular regulation, pathophysiology and therapeutics ii |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
physical |
1 electronic resource (176 p.) |
isbn |
3-03936-435-9 3-03936-436-7 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT deindlelisabeth arteriogenesismolecularregulationpathophysiologyandtherapeuticsii AT quaxpaul arteriogenesismolecularregulationpathophysiologyandtherapeuticsii AT deindlelisabeth arteriogenesis AT quaxpaul arteriogenesis |
status_str |
n |
ids_txt_mv |
(CKB)5400000000041177 (oapen)https://directory.doabooks.org/handle/20.500.12854/68862 (EXLCZ)995400000000041177 |
carrierType_str_mv |
cr |
is_hierarchy_title |
Arteriogenesis Molecular Regulation, Pathophysiology and Therapeutics II |
author2_original_writing_str_mv |
noLinkedField noLinkedField noLinkedField |
_version_ |
1796652236410978304 |
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