Spumaretroviruses

Spumaretroviruses

Foamy viruses, currently referred to as spumaretroviruses, are the most ancient retroviruses as evidenced by traces of viral sequences dispersed in all vertebrate classes from fish to mammals. Additionally, infectious foamy viruses circulate in a variety of mammalian species including simian, bovine...

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HerausgeberIn:
Löchelt, Martin
Lindemann, Dirk
Sonstige:
Khan, Arifa
Löchelt, Martin
Lindemann, Dirk
Year of Publication:2021
Language:English
Physical Description:1 electronic resource (352 p.)
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id 993545536304498
ctrlnum (CKB)5400000000043585
(oapen)https://directory.doabooks.org/handle/20.500.12854/76747
(EXLCZ)995400000000043585
collection bib_alma
record_format marc
spelling Khan, Arifa edt
Spumaretroviruses
Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
1 electronic resource (352 p.)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Foamy viruses, currently referred to as spumaretroviruses, are the most ancient retroviruses as evidenced by traces of viral sequences dispersed in all vertebrate classes from fish to mammals. Additionally, infectious foamy viruses circulate in a variety of mammalian species including simian, bovine, equine, caprine, and feline. Foamy viruses have many unique features which led to the division of the retrovirus family into two subfamilies, the Orthoretrovirinae and Spumaretrovirinae. In vitro, foamy viruses have a broad host range and in vivo, human infections have been described due to cross-species transmission from infected nonhuman primates. Thus far, there are no reports of virus-induced disease in humans or in the natural host species. These unique properties of foamy viruses have led researchers to develop foamy viruses as gene therapy vectors to study virus–virus and virus–host interactions for identifying factors involved in virus replication, transmission, and immune regulation that could influence potential clinical outcomes in humans as well as for using endogenous foamy virus sequences in the analysis of host species evolution.
English
Medicine bicssc
Neurosciences bicssc
spumavirus
feline illness
proviral load
neglected virus
bovine foamy virus
infectious clone
particle release
cell-free transmission
foamy virus
spumaretrovirus
cross-species virus transmission
zoonosis
restriction factors
immune responses
FV vectors
virus replication
latent infection
feline foamy virus
epidemiology
retrovirus
Spumaretrovirus
mountain lion
Puma concolor
ELISA
protease
reverse transcriptase
RNase H
reverse transcription
antiviral drugs
resistance
simian foamy virus
gibbon
lesser apes
co-evolution
complete viral genome
equine foamy virus
isolation
Japan
sero-epidemiology
reptile foamy virus
endogenous foamy virus
endogenous retrovirus
ancient retroviruses
co-speciation
foamy virus-host interactions
viral tropism
infection
kidney
cats
chronic kidney disease
chronic renal disease
integrase
integration
co-infections
NHP
pathogenesis
zoonoses
viral prevalence
Neotropical primates
free-living primates
Brazil
new world primates
simian retrovirus
BFV
spuma virus
model system
animal model
animal experiment
miRNA function
gene expression
antiviral host restriction
gene therapy
in-vivo gene therapy
hematopoietic stem and progenitor cells
foamy virus vector
pre-clinical canine model
SCID-X1
innate sensing
cGAS
STING
foamy viruses
wild ruminants
European bison
red deer
roe deer
fallow deer
seroreactivity
inter-species transmission
HSC
gene marking
FV gene transfer to HSCs
gene therapy alternatives
serotype
high-throughput sequencing
replication kinetics
cytopathic effect
reverse transcriptase activity
miRNA expression
virus-host-interaction
miRNA target gene identification
innate immunity
ANKRD17
Bif1 (SH3GLB1)
replication in vitro
3-0365-0594-6
3-0365-0595-4
Löchelt, Martin edt
Lindemann, Dirk edt
Khan, Arifa oth
Löchelt, Martin oth
Lindemann, Dirk oth
language English
format eBook
author2 Löchelt, Martin
Lindemann, Dirk
Khan, Arifa
Löchelt, Martin
Lindemann, Dirk
author_facet Löchelt, Martin
Lindemann, Dirk
Khan, Arifa
Löchelt, Martin
Lindemann, Dirk
author2_variant a k ak
m l ml
d l dl
author2_role HerausgeberIn
HerausgeberIn
Sonstige
Sonstige
Sonstige
title Spumaretroviruses
spellingShingle Spumaretroviruses
title_full Spumaretroviruses
title_fullStr Spumaretroviruses
title_full_unstemmed Spumaretroviruses
title_auth Spumaretroviruses
title_new Spumaretroviruses
title_sort spumaretroviruses
publisher MDPI - Multidisciplinary Digital Publishing Institute
publishDate 2021
physical 1 electronic resource (352 p.)
isbn 3-0365-0594-6
3-0365-0595-4
illustrated Not Illustrated
work_keys_str_mv AT khanarifa spumaretroviruses
AT locheltmartin spumaretroviruses
AT lindemanndirk spumaretroviruses
status_str n
ids_txt_mv (CKB)5400000000043585
(oapen)https://directory.doabooks.org/handle/20.500.12854/76747
(EXLCZ)995400000000043585
carrierType_str_mv cr
is_hierarchy_title Spumaretroviruses
author2_original_writing_str_mv noLinkedField
noLinkedField
noLinkedField
noLinkedField
noLinkedField
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