Marine Natural Products as Anticancer Agents
Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug deve...
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Alves, Celso edt Marine Natural Products as Anticancer Agents Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (150 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment. English Medicine bicssc alga marine-derived fungus Penicillium chrysogenum polyketide hydroxyphenylacetic acid cytotoxicity flaccidoxide-13-acetate hepatocellular carcinoma invasion migration epithelial-mesenchymal transition prostate cancer astaxanthin STAT3 proliferation colony formation apoptosis Sarcophyton digitatum biscembranoid-type metabolites inflammatory factor production LPS-stimulated murine macrophage Ehlich's tumor P. purpurogenum antitumor meroterpenoids inflammation T47D BT20 pontin mutp53 cancer stem cells Oct4 Nanog siRNA secondary metabolites epigenome epigenetic signaling bioactive compounds cancer therapy marine species environment total synthesis natural product nannocystin anti-cancer gram-scale aplysinopsin analogs indole alkaloids marine source chronic myeloid leukemia BH3 mimetics 3-0365-1820-7 3-0365-1819-3 Diederich, Marc edt Alves, Celso oth Diederich, Marc oth |
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English |
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author2 |
Diederich, Marc Alves, Celso Diederich, Marc |
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Diederich, Marc Alves, Celso Diederich, Marc |
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c a ca m d md |
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HerausgeberIn Sonstige Sonstige |
title |
Marine Natural Products as Anticancer Agents |
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Marine Natural Products as Anticancer Agents |
title_full |
Marine Natural Products as Anticancer Agents |
title_fullStr |
Marine Natural Products as Anticancer Agents |
title_full_unstemmed |
Marine Natural Products as Anticancer Agents |
title_auth |
Marine Natural Products as Anticancer Agents |
title_new |
Marine Natural Products as Anticancer Agents |
title_sort |
marine natural products as anticancer agents |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
physical |
1 electronic resource (150 p.) |
isbn |
3-0365-1820-7 3-0365-1819-3 |
illustrated |
Not Illustrated |
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AT alvescelso marinenaturalproductsasanticanceragents AT diederichmarc marinenaturalproductsasanticanceragents |
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Marine Natural Products as Anticancer Agents |
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