New Developments in the Pathogenesis of Rheumatoid Arthritis /

New Developments in the Pathogenesis of Rheumatoid Arthritis / / edited by Lazaros I. Sakkas.

The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-...

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Lazaros I. Sakkas
TeilnehmendeR:
Sakkas, Lazaros I.,
Place / Publishing House:[Place of publication not identified] : : IntechOpen,, 2017.
Year of Publication:2017
Language:English
Physical Description:1 online resource (164 pages)
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New Developments in the Pathogenesis of Rheumatoid Arthritis / edited by Lazaros I. Sakkas.
IntechOpen 2017
[Place of publication not identified] : IntechOpen, 2017.
1 online resource (164 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Description based on: online resource; title from PDF information screen (InTech, viewed October 20, 2022).
Includes bibliographical references and index.
The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.
English
Rheumatoid arthritis.
Medicine
Immunology
Osteoimmunology
Allergology and Rheumatology
Health Sciences
953-51-2969-4
Sakkas, Lazaros I., editor.
language English
format eBook
author Lazaros I. Sakkas
spellingShingle Lazaros I. Sakkas
New Developments in the Pathogenesis of Rheumatoid Arthritis /
author_facet Lazaros I. Sakkas
Sakkas, Lazaros I.,
author_variant l i s lis
author2 Sakkas, Lazaros I.,
author2_variant l i s li lis
author2_role TeilnehmendeR
author_sort Lazaros I. Sakkas
title New Developments in the Pathogenesis of Rheumatoid Arthritis /
title_full New Developments in the Pathogenesis of Rheumatoid Arthritis / edited by Lazaros I. Sakkas.
title_fullStr New Developments in the Pathogenesis of Rheumatoid Arthritis / edited by Lazaros I. Sakkas.
title_full_unstemmed New Developments in the Pathogenesis of Rheumatoid Arthritis / edited by Lazaros I. Sakkas.
title_auth New Developments in the Pathogenesis of Rheumatoid Arthritis /
title_new New Developments in the Pathogenesis of Rheumatoid Arthritis /
title_sort new developments in the pathogenesis of rheumatoid arthritis /
publisher IntechOpen
IntechOpen,
publishDate 2017
physical 1 online resource (164 pages)
isbn 953-51-7342-1
953-51-2970-8
953-51-2969-4
callnumber-first R - Medicine
callnumber-subject RC - Internal Medicine
callnumber-label RC933
callnumber-sort RC 3933 N493 42017
illustrated Not Illustrated
dewey-hundreds 600 - Technology
dewey-tens 610 - Medicine & health
dewey-ones 616 - Diseases
dewey-full 616.7227
dewey-sort 3616.7227
dewey-raw 616.7227
dewey-search 616.7227
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carrierType_str_mv cr
is_hierarchy_title New Developments in the Pathogenesis of Rheumatoid Arthritis /
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