Structure, Activity, and Function of Protein Methyltransferases

Structure, Activity, and Function of Protein Methyltransferases

This collection of review articles describes the structure, function and mechanism of individual protein methyltransferase enzymes including protein lysine methyltransferases, protein arginine methyltransferases, and also the less abundant protein histidine methyltransferases and protein N-terminal...

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HerausgeberIn:
Dhayalan, Arunkumar
Sonstige:
Jeltsch, Albert
Dhayalan, Arunkumar
Year of Publication:2022
Language:English
Physical Description:1 electronic resource (292 p.)
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id 993545305604498
ctrlnum (CKB)5680000000037584
(oapen)https://directory.doabooks.org/handle/20.500.12854/81233
(EXLCZ)995680000000037584
collection bib_alma
record_format marc
spelling Jeltsch, Albert edt
Structure, Activity, and Function of Protein Methyltransferases
Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
1 electronic resource (292 p.)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
This collection of review articles describes the structure, function and mechanism of individual protein methyltransferase enzymes including protein lysine methyltransferases, protein arginine methyltransferases, and also the less abundant protein histidine methyltransferases and protein N-terminal end methyltransferases. The topics covered in the individual reviews include structural aspects (domain architecture, homologs and paralogs, and structure), biochemical properties (mechanism, sequence specificity, product specificity, regulation, and histone and non-histone substrates), cellular features (subcellular localization, expression patterns, cellular roles and function, biological effects of substrate protein methylation, connection to cell signaling pathways, and connection to chromatin regulation) and their role in diseases. This review book is a useful resource for scientists working on protein methylation and protein methyltransferases and those interested in joining this emerging research field.
English
Research & information: general bicssc
Biology, life sciences bicssc
Biochemistry bicssc
protein lysine methylation
H3K9 methylation
PKMT
enzyme specificity
enzyme regulation
heterochromatin
protein post-translational modification
NSD3
WHSC1L1
structure and function
protein arginine methylation
PRMT7
epigenetics
cancer
immunity
pluripotency
SETDB1
methyltransferase
schizophrenia
Huntington's disease
Rett syndrome
Prader-Willi syndrome
congenital heart diseases
inflammatory bowel disease
MLL2
structure
H3K4me3
chromatin regulation
disease
dystonia
NSD1
H3K36
SOTOS
NUP98-NSD1
AML
PRMT6
post-translational modification
H3R2me2a
SETD3
posttranslational modifications
protein histidine methylation
actin
polymerization
cytoskeleton
enteroviruses
oncogenesis
PRMT5
cardiovascular disease
neurodegenerative diseases
diabetes
inflammation
G9a
GLP
EHMT2
EHMT1
post translational modification
lysine methylation
N-terminal methylation
translation
eEF1A
METTL13
neuron
synapse
dendritic spine
actin cytoskeleton
GTPase
PRMT1
arginine methylation
H4R3 methylation
transcriptional regulation
cell signaling
DNA damage repair
PRMT2
SH3
SETMAR
Metnase
H3K36me2
Hsmar1
non-homologous end joining repair
NHEJ
transposase
transposable elements
histone
SET7/9
SETD7
lysine-specific methyltransferase (PKMT)
cell proliferation
stress response
post-translational protein modification
3-0365-4139-X
3-0365-4140-3
Dhayalan, Arunkumar edt
Jeltsch, Albert oth
Dhayalan, Arunkumar oth
language English
format eBook
author2 Dhayalan, Arunkumar
Jeltsch, Albert
Dhayalan, Arunkumar
author_facet Dhayalan, Arunkumar
Jeltsch, Albert
Dhayalan, Arunkumar
author2_variant a j aj
a d ad
author2_role HerausgeberIn
Sonstige
Sonstige
title Structure, Activity, and Function of Protein Methyltransferases
spellingShingle Structure, Activity, and Function of Protein Methyltransferases
title_full Structure, Activity, and Function of Protein Methyltransferases
title_fullStr Structure, Activity, and Function of Protein Methyltransferases
title_full_unstemmed Structure, Activity, and Function of Protein Methyltransferases
title_auth Structure, Activity, and Function of Protein Methyltransferases
title_new Structure, Activity, and Function of Protein Methyltransferases
title_sort structure, activity, and function of protein methyltransferases
publisher MDPI - Multidisciplinary Digital Publishing Institute
publishDate 2022
physical 1 electronic resource (292 p.)
isbn 3-0365-4139-X
3-0365-4140-3
illustrated Not Illustrated
work_keys_str_mv AT jeltschalbert structureactivityandfunctionofproteinmethyltransferases
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status_str n
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carrierType_str_mv cr
is_hierarchy_title Structure, Activity, and Function of Protein Methyltransferases
author2_original_writing_str_mv noLinkedField
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noLinkedField
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