A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research
During the last 60 years the relevance of cannabis (Cannabis sativa or Cannabis indica) ingredients, like the psychoactive Δ9-tetrahydrocannabinol (THC), cannabidiol, 120+ additional cannabinoids and 440+ non-cannabinoid compounds, for human health and disease has become apparent. Approximately 30 y...
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Maccarrone, Mauro edt A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research Themed Issue in Honor of Professor Raphael Mechoulam Basel MDPI - Multidisciplinary Digital Publishing Institute 2022 1 electronic resource (236 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier During the last 60 years the relevance of cannabis (Cannabis sativa or Cannabis indica) ingredients, like the psychoactive Δ9-tetrahydrocannabinol (THC), cannabidiol, 120+ additional cannabinoids and 440+ non-cannabinoid compounds, for human health and disease has become apparent. Approximately 30 years after the elucidation of THC structure the molecular reasons for the biological activity of these plant extracts were made clearer by the discovery of endocannabinoids, that are endogenous lipids able to bind to the same receptors activated by THC. Besides endocannabinoids, that include several N-acylethanolamines and acylesters, a complex array of receptors, metabolic enzymes, transporters (transmembrane, intracellular and extracellular carriers) were also discovered, and altogether they form a so-called “endocannabinoid system” that has been shown to finely tune the manifold biological activities of these lipid signals. Both plant-derived cannabinoids and endocannabinoids were first discovered by the group led by Prof. Dr. Raphael Mechoulam, who has just celebrated his 90th birthday and clearly stood out as a giant of modern science. The many implications of his seminal work for chemistry, biochemistry, biology, pharmacology and medicine are described in this special issue by the scientists who reached during the last 20 years the highest recognition in the field of (endo)cannabinoid research, receiving the Mechoulam Award for their major contributions. I thank them for having accepted my invitation to be part of this honorary issue of Molecules, and Raphi for continuing to illuminate our field with his always inspiring investigations and new ideas. English Research & information: general bicssc Biology, life sciences bicssc Biochemistry bicssc cannabinoid MRI-1867 hybrid ligand CB1 receptor antagonist iNOS inhibitor rimonabant intracerebroventricular administration alcohol craving two-bottle paradigm drinking in the dark N-acyltransferase anandamide endocannabinoid phospholipase A2 cannabichromene cannabidiolic acid cannabidivarin cannabidivarinic acid phytocannabinoids tetrahydrocannabivarin 4'-fluoro-cannabidiol cannabinoid tetrad elevated plus maze catalepsy marble bury HUF-101 equilibrative nucleoside transporter CB1 biased signaling functional selectivity G-protein β-arrestin cannabigerol anti-inflammatory obesity cannabinoid receptor 2 (CB2R) microglia inflammaging memory lipofuscin aminoalkylindole allodynia antinociception cannabinoid receptor CP55940 JWH-018 K2 pravadoline spice WIN55212-2 type 1 cannabinoid receptor CB1 cholesterol hippocampus frontal cortex synaptosomes rescue model anti-CB1 antibody cannabinoids GPR55 receptors VCE-006.1 chromenopyrazole Parkinson's disease 6-hydroxydopamine lipopolysaccharide amyotrophic lateral sclerosis mSOD1 mice TDP-43 transgenic mice PPARs gut microbiome intestine ghrelin LEAP2 3-0365-3006-1 3-0365-3007-X Maccarrone, Mauro oth |
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English |
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Maccarrone, Mauro |
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Maccarrone, Mauro |
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title |
A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
spellingShingle |
A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
title_full |
A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
title_fullStr |
A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
title_full_unstemmed |
A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
title_auth |
A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
title_alt |
Themed Issue in Honor of Professor Raphael Mechoulam |
title_new |
A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
title_sort |
a themed issue in honor of professor raphael mechoulam: the father of cannabinoid and endocannabinoid research |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
physical |
1 electronic resource (236 p.) |
isbn |
3-0365-3006-1 3-0365-3007-X |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT maccarronemauro athemedissueinhonorofprofessorraphaelmechoulamthefatherofcannabinoidandendocannabinoidresearch AT maccarronemauro themedissueinhonorofprofessorraphaelmechoulam |
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A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research |
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