The Role of Extracellular Matrix in Cancer Development and Progression
The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasa...
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Tzanakakis, George edt The Role of Extracellular Matrix in Cancer Development and Progression Basel MDPI - Multidisciplinary Digital Publishing Institute 2022 1 electronic resource (182 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research. English Research & information: general bicssc elastin ribosomal protein SA tongue carcinoma MMP-2 EGCG pancreatic ductal adenocarcinoma syndecans proteoglycans tumor progression angiogenesis syndecan-4 heparan sulfate cancer prognosis biomarker signal transduction proteoglycan metastasis extracellular matrix fibrosis immune cell modulation neutrophils neutrophil extracellular trap macrophages BCC MMP TIMP invasion lumican cancer cell growth motility hyaluronan RHAMM CD44 wound repair breast cancer malignant pleural mesothelioma pleural effusion extracellular vesicles biomarkers sulfated hyaluronan estrogen receptors epithelial-to-mesenchymal transition matrix metalloproteinases 3-0365-3405-9 3-0365-3406-7 Nikitovic, Dragana edt Tzanakakis, George oth Nikitovic, Dragana oth |
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English |
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Nikitovic, Dragana Tzanakakis, George Nikitovic, Dragana |
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Nikitovic, Dragana Tzanakakis, George Nikitovic, Dragana |
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HerausgeberIn Sonstige Sonstige |
title |
The Role of Extracellular Matrix in Cancer Development and Progression |
spellingShingle |
The Role of Extracellular Matrix in Cancer Development and Progression |
title_full |
The Role of Extracellular Matrix in Cancer Development and Progression |
title_fullStr |
The Role of Extracellular Matrix in Cancer Development and Progression |
title_full_unstemmed |
The Role of Extracellular Matrix in Cancer Development and Progression |
title_auth |
The Role of Extracellular Matrix in Cancer Development and Progression |
title_new |
The Role of Extracellular Matrix in Cancer Development and Progression |
title_sort |
the role of extracellular matrix in cancer development and progression |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
physical |
1 electronic resource (182 p.) |
isbn |
3-0365-3405-9 3-0365-3406-7 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT tzanakakisgeorge theroleofextracellularmatrixincancerdevelopmentandprogression AT nikitovicdragana theroleofextracellularmatrixincancerdevelopmentandprogression |
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The Role of Extracellular Matrix in Cancer Development and Progression |
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