The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria
Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby...
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| Year of Publication: | 2022 |
| Language: | English |
| Physical Description: | 1 electronic resource (190 p.) |
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Broutin, Isabelle edt The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria Basel MDPI - Multidisciplinary Digital Publishing Institute 2022 1 electronic resource (190 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens. English Research & information: general bicssc Biology, life sciences bicssc Microbiology (non-medical) bicssc MdtF (YhiV) multidrug resistance RND-type efflux pump dye accumulation real-time efflux pathogens RND evolution efflux pump adaptation Aliarcobacter butzleri RND efflux pumps virulence resistance RND pump dominant negative effect assembly protein-protein interaction mutation drug resistance cystic fibrosis prevalence of efflux resistance mechanisms hospital acquired infections antibiotic resistance allostery antimicrobial resistance conformational changes energetic transition gram-negative bacteria pump activation n/a 3-0365-3946-8 3-0365-3945-X Vargiu, Attilio V edt Venter, Henrietta edt Phan, Gilles edt Broutin, Isabelle oth Vargiu, Attilio V oth Venter, Henrietta oth Phan, Gilles oth |
| language |
English |
| format |
eBook |
| author2 |
Vargiu, Attilio V Venter, Henrietta Phan, Gilles Broutin, Isabelle Vargiu, Attilio V Venter, Henrietta Phan, Gilles |
| author_facet |
Vargiu, Attilio V Venter, Henrietta Phan, Gilles Broutin, Isabelle Vargiu, Attilio V Venter, Henrietta Phan, Gilles |
| author2_variant |
i b ib a v v av avv h v hv g p gp |
| author2_role |
HerausgeberIn HerausgeberIn HerausgeberIn Sonstige Sonstige Sonstige Sonstige |
| title |
The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| spellingShingle |
The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_full |
The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_fullStr |
The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_full_unstemmed |
The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_auth |
The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_new |
The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
| title_sort |
the structural and functional study of efflux pumps belonging to the rnd transporters family from gram-negative bacteria |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2022 |
| physical |
1 electronic resource (190 p.) |
| isbn |
3-0365-3946-8 3-0365-3945-X |
| illustrated |
Not Illustrated |
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(CKB)5680000000037611 (oapen)https://directory.doabooks.org/handle/20.500.12854/81046 (EXLCZ)995680000000037611 |
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The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria |
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