Role of MicroRNA in Cancer Development and Treatment
Many researchers around the world have demonstrated that the expression of miRNAs is dysregulated in different tumors. Such dysregulation is caused by multiple mechanisms, and exposure to different carcinogens causes dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. Canc...
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Physical Description: | 1 electronic resource (280 p.) |
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Pulliero, Alessandra edt Role of MicroRNA in Cancer Development and Treatment Basel MDPI - Multidisciplinary Digital Publishing Institute 2022 1 electronic resource (280 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Many researchers around the world have demonstrated that the expression of miRNAs is dysregulated in different tumors. Such dysregulation is caused by multiple mechanisms, and exposure to different carcinogens causes dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. Cancer cells with abnormal miRNA expression evolve the capability to sustain proliferative signaling, evade growth suppressors, resist cell death, activate invasion and metastasis, and induce angiogenesis. Genome-wide profiling demonstrates that miRNA expression signatures are associated with tumor type, tumor grade and clinical outcomes, so miRNAs could be potential candidates for diagnostic biomarkers, prognostic biomarkers, therapeutic targets and preventive screening programs. Although miRNAs have multiple targets, their function in tumorigenesis is due to their regulation of a few specific targets. After the first detection of altered miRNA in leukemia, microRNAs have been demonstrated to be constantly altered in all cancer. More recently, microRNA has been shown to be altered by exposure to environmental carcinogens, thus driving the whole process of carcinogenesis. Our aim is to provide a rigorous peer review and publish cutting-edge research on the role of microRNA in cancer prevention therapy to educate and inspire the scientific community worldwide. English Medicine bicssc Pharmacology bicssc breast cancer miRNAs liquid biopsy angiogenesis biomarkers early diagnosis air pollution biomarker exposure human lung cancer miRNA carcinogenesis microRNA asbestos exposure oral squamous cell carcinoma diagnosis prognosis saliva neuroblastoma MYCN amplification metastases chemoresistance public health genomics genetic polymorphisms epigenetic modulations genetic and microbiome markers health technology assessment early disease prevention nonsmokers lung cancer environmental risk factors oncogenes mutations glioblastoma microRNAs cancer qPCR cancer stem cells plasticizers in vitro study PRISMA no-smokers lung cancer DNA adducts mesothelioma extracellular vesicles miR-625 fluoro-edenite asbestos malignant mesothelioma cancer prevention microbiota epigenetics environmental pollutants cutaneous tissues ozone exposure 3-0365-3806-2 3-0365-3805-4 Izzotti, Alberto edt Pulliero, Alessandra oth Izzotti, Alberto oth |
language |
English |
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eBook |
author2 |
Izzotti, Alberto Pulliero, Alessandra Izzotti, Alberto |
author_facet |
Izzotti, Alberto Pulliero, Alessandra Izzotti, Alberto |
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a p ap a i ai |
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HerausgeberIn Sonstige Sonstige |
title |
Role of MicroRNA in Cancer Development and Treatment |
spellingShingle |
Role of MicroRNA in Cancer Development and Treatment |
title_full |
Role of MicroRNA in Cancer Development and Treatment |
title_fullStr |
Role of MicroRNA in Cancer Development and Treatment |
title_full_unstemmed |
Role of MicroRNA in Cancer Development and Treatment |
title_auth |
Role of MicroRNA in Cancer Development and Treatment |
title_new |
Role of MicroRNA in Cancer Development and Treatment |
title_sort |
role of microrna in cancer development and treatment |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
physical |
1 electronic resource (280 p.) |
isbn |
3-0365-3806-2 3-0365-3805-4 |
illustrated |
Not Illustrated |
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AT pullieroalessandra roleofmicrornaincancerdevelopmentandtreatment AT izzottialberto roleofmicrornaincancerdevelopmentandtreatment |
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(CKB)5720000000008389 (oapen)https://directory.doabooks.org/handle/20.500.12854/84450 (EXLCZ)995720000000008389 |
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Role of MicroRNA in Cancer Development and Treatment |
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