PPARs as Key Mediators of Metabolic and Inflammatory Regulation
Mounting evidence suggests a bidirectional relationship between metabolism and inflammation. Molecular crosstalk between these processes occurs at different levels with the participation of nuclear receptors, including peroxisome proliferator-activated receptors (PPARs). There are three PPAR isotype...
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| Year of Publication: | 2022 |
| Language: | English |
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Vázquez-Carrera, Manuel edt PPARs as Key Mediators of Metabolic and Inflammatory Regulation MDPI - Multidisciplinary Digital Publishing Institute 2022 1 electronic resource (456 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Mounting evidence suggests a bidirectional relationship between metabolism and inflammation. Molecular crosstalk between these processes occurs at different levels with the participation of nuclear receptors, including peroxisome proliferator-activated receptors (PPARs). There are three PPAR isotypes, α, β/δ, and γ, which modulate metabolic and inflammatory pathways, making them key for the control of cellular, organ, and systemic processes. PPAR activity is governed by fatty acids and fatty acid derivatives, and by drugs used in clinics (glitazones and fibrates). The study of PPAR action, also modulated by post-translational modifications, has enabled extraordinary advances in the understanding of the multifaceted roles of these receptors in metabolism, energy homeostasis, and inflammation both in health and disease. This Special Issue of IJMS includes a broad range of basic and translational article, both original research and reviews, focused on the latest developments in the regulation of metabolic and/or inflammatory processes by PPARs in all organs and the microbiomes of different vertebrate species. English Research & information: general bicssc Biology, life sciences bicssc Biochemistry bicssc nuclear receptor gene transcription inflammation molecular docking PPARβ/δ lung pulmonary artery GW0742 GSK3787 docking lipopolysaccharide (LPS) PPARγ ligand coumarin fluorescent ligand screening crystal structure PPAR atopic dermatitis psoriasis metabolic reprograming glucose fatty acids mycobacteria M. tuberculosis M. leprae PPARs lipid droplets metabolic alterations hepatic damage nuclear factors pharmacological targets AMPK GDF15 insulin resistance type 2 diabetes mellitus peroxisome proliferator-activated receptor gamma (PPARγ) real-time PCR ELISA immunohistochemistry signaling pathway PPAR gamma brain neural stem cells infection neuroinflammation HIV Zika cytomegalovirus neurogenesis microglia liver damage toll-like receptor 4 P2Y2 receptor metabolic syndrome resveratrol quercetin PPARα peroxisome β-oxidation PPRE ligand coregulator micronutrients PPARα knockout adipose tissue browning lipid metabolism depression PPARg neuropathology corticotropin releasing hormone norepinephrine subgenual prefrontal cortex amygdala nucleus accumbens common carotid artery occlusion electroretinography fibroblast growth factor 21 pemafibrate peroxisome proliferator-activated receptor alpha retinal ischemia skeletal muscle substrate metabolism nonalcoholic fatty liver disease (NAFLD) sex dimorphism lipidomics hepatic sex-biased gene expression PPARγ pulmonary arterial hypertension TGFβ vascular injury proliferation kidney fibrosis pattern-recognition receptors phagocytosis nitric oxide synthase fenofibrate oleoylethanolamide palmitoylethanolamide cancer immunity obesity diabetes miRNA DNA methylation histone modification peroxisome-proliferator-activated receptor fatty acid oxidation doping control regulatory T cells exercise nuclear receptors nutrigenomics energy homeostasis dairy animals non-alcoholic fatty liver disease (NAFLD) non-alcoholic steatohepatitis (NASH) peroxisome proliferator-activated receptors (PPAR) bezafibrate fenofibric acid peroxisome proliferator-activated receptor dual/pan agonist X-ray crystallography 3-0365-4192-6 3-0365-4191-8 Wahli, Walter edt Vázquez-Carrera, Manuel oth Wahli, Walter oth |
| language |
English |
| format |
eBook |
| author2 |
Wahli, Walter Vázquez-Carrera, Manuel Wahli, Walter |
| author_facet |
Wahli, Walter Vázquez-Carrera, Manuel Wahli, Walter |
| author2_variant |
m v c mvc w w ww |
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HerausgeberIn Sonstige Sonstige |
| title |
PPARs as Key Mediators of Metabolic and Inflammatory Regulation |
| spellingShingle |
PPARs as Key Mediators of Metabolic and Inflammatory Regulation |
| title_full |
PPARs as Key Mediators of Metabolic and Inflammatory Regulation |
| title_fullStr |
PPARs as Key Mediators of Metabolic and Inflammatory Regulation |
| title_full_unstemmed |
PPARs as Key Mediators of Metabolic and Inflammatory Regulation |
| title_auth |
PPARs as Key Mediators of Metabolic and Inflammatory Regulation |
| title_new |
PPARs as Key Mediators of Metabolic and Inflammatory Regulation |
| title_sort |
ppars as key mediators of metabolic and inflammatory regulation |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2022 |
| physical |
1 electronic resource (456 p.) |
| isbn |
3-0365-4192-6 3-0365-4191-8 |
| illustrated |
Not Illustrated |
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AT vazquezcarreramanuel pparsaskeymediatorsofmetabolicandinflammatoryregulation AT wahliwalter pparsaskeymediatorsofmetabolicandinflammatoryregulation |
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PPARs as Key Mediators of Metabolic and Inflammatory Regulation |
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