Opioids and Their Receptors : Present and Emerging Concepts in Opioid Drug Discovery II
Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modula...
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| Year of Publication: | 2022 |
| Language: | English |
| Physical Description: | 1 electronic resource (260 p.) |
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Spetea, Mariana edt Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II Opioids and Their Receptors Basel MDPI - Multidisciplinary Digital Publishing Institute 2022 1 electronic resource (260 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modulating a large number of sensory, motivational, emotional and cognitive functions. Additionally, its important therapeutic value for the treatment of many human disorders, including pain, affective and addictive disorders, and gastrointestinal motility disorders, has been of persistent interest. This book specifically covers a broad area of the opioid research, offering up-to-date and new perspectives about opioid drug discovery. The diversity among the discussed topics ranging from medicinal chemistry to opioid pharmacology, from basic science to translational research, is a testimony to the complexity of the opioid system that results from the expression, regulation and functional role of opioid ligands and their receptors. This book will serve as a useful reference to scientists while also stimulating continuous research in the chemistry and pharmacology of the opioid system, with the prospective for finding improved therapies of human diseases where the opioid system plays a central role. English Research & information: general bicssc Chemistry bicssc thiazole piperazine tail-clip hot-plate acetic acid-induced writhing test opioid prodynorphin epigenetics transcription human brain morphine dosing behavior locomotor activity tolerance µ-opioid receptor DAMGO SR-17018 buprenorphine nalbuphine kappa opioid receptor agonist pruritis scratching mice TAT-HIV cholestasis chloroquine deoxycholic acid analgesic δ opioid receptor G-protein-biased agonist opioid peptide rubiscolins µ-opioid analgesics angiotensin receptors chronic pain neuropathic pain delta opioid receptor inverse agonist irreversible antagonist non-competitive antagonist molecular pharmacology free fatty acid receptors lipids opioid receptor colitis chemotype high-throughput screen allosteric modulation beta-arrestin molecular dynamics opioid receptors β-amino acids peptide synthesis receptor binding studies functional assay nociceptin/orphanin FQ receptor NOP receptor ligands nociceptin N/OFQ analgesia GPCR HS-731 peripheral opioid agonist binding selectivity molecular docking molecular dynamics simulations fluorescence cross-correlation spectroscopy (FCCS) G protein-coupled receptor (GPCR) serotonin 3-0365-4352-X 3-0365-4351-1 van Rijn, Richard M. edt Spetea, Mariana oth van Rijn, Richard M. oth |
| language |
English |
| format |
eBook |
| author2 |
van Rijn, Richard M. Spetea, Mariana van Rijn, Richard M. |
| author_facet |
van Rijn, Richard M. Spetea, Mariana van Rijn, Richard M. |
| author2_variant |
m s ms r r m v rrm rrmv |
| author2_role |
HerausgeberIn Sonstige Sonstige |
| title |
Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II |
| spellingShingle |
Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II |
| title_sub |
Present and Emerging Concepts in Opioid Drug Discovery II |
| title_full |
Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II |
| title_fullStr |
Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II |
| title_full_unstemmed |
Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II |
| title_auth |
Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II |
| title_alt |
Opioids and Their Receptors |
| title_new |
Opioids and Their Receptors |
| title_sort |
opioids and their receptors present and emerging concepts in opioid drug discovery ii |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2022 |
| physical |
1 electronic resource (260 p.) |
| isbn |
3-0365-4352-X 3-0365-4351-1 |
| illustrated |
Not Illustrated |
| work_keys_str_mv |
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cr |
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Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II |
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