Single-Domain Antibodies: Biology, Engineering and Emerging Applications
Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but c...
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| Superior document: | Frontiers Research Topics |
|---|---|
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| Year of Publication: | 2018 |
| Language: | English |
| Series: | Frontiers Research Topics
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| Physical Description: | 1 electronic resource (338 p.) |
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(CKB)4920000000094211 (oapen)https://directory.doabooks.org/handle/20.500.12854/59417 (EXLCZ)994920000000094211 |
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Kevin A. Henry auth Single-Domain Antibodies: Biology, Engineering and Emerging Applications Single-Domain Antibodies Frontiers Media SA 2018 1 electronic resource (338 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics. English antibody engineering antibody discovery therapeutic antibody diagnostic antibody single-domain antibody 2-88945-432-0 C. Roger MacKenzie auth |
| language |
English |
| format |
eBook |
| author |
Kevin A. Henry |
| spellingShingle |
Kevin A. Henry Single-Domain Antibodies: Biology, Engineering and Emerging Applications Frontiers Research Topics |
| author_facet |
Kevin A. Henry C. Roger MacKenzie |
| author_variant |
k a h kah |
| author2 |
C. Roger MacKenzie |
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c r m crm |
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Kevin A. Henry |
| title |
Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_full |
Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_fullStr |
Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_full_unstemmed |
Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_auth |
Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_alt |
Single-Domain Antibodies |
| title_new |
Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_sort |
single-domain antibodies: biology, engineering and emerging applications |
| series |
Frontiers Research Topics |
| series2 |
Frontiers Research Topics |
| publisher |
Frontiers Media SA |
| publishDate |
2018 |
| physical |
1 electronic resource (338 p.) |
| isbn |
2-88945-432-0 |
| illustrated |
Not Illustrated |
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