AMP-Activated Protein Kinase Signalling
Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Struc...
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| Year of Publication: | 2019 |
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| Physical Description: | 1 electronic resource (452 p.) |
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Neumann, Dietbert auth AMP-Activated Protein Kinase Signalling MDPI - Multidisciplinary Digital Publishing Institute 2019 1 electronic resource (452 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Open access Unrestricted online access star Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included. English HDACs transcription epigenetics spermatozoa par complex A769662 MDCK skeletal muscle AID phosphorylation energy metabolism monocytes autophagy CML liver hindlimb suspension pregnancy preeclampsia gestational diabetes mellitus CaMKK2 assisted reproduction techniques nutrient-sensing signals sonic hedgehog protein acetylation glycogen storage disease AMPK adenosine monophosphate-activated protein kinase AICAR indirect calorimetry IL-1? MyHC I(?) HDAC4/5 endothelial cells infection hepatocyte p70S6K lipid metabolism host defense exercise kidney disease heat shock protein ?RIM mycobacteria activation loop developmental origins of health and disease (DOHaD) CREB TAK1 metabolic-inflammation phenylephrine AMP-activated protein kinase (AMPK) KATs 2-methoxyestradiol DNA methylation NLRP3 pump ?-linker steatosis AMPK kinase stress endothelial nitric-oxide synthase vasodilation adherent junctions epithelial cells glycogen Akt synaptic activation cellular energy sensing glucose uptake transporter co-expression atrophy nutrigenomics motility vasoconstriction fatty acid oxidation oxidative stress AS160 membrane histone modification sirtuin 1 (SIRT1) chromatin remodeling insulin signalling dietary fatty acids ULK CMML adaptive thermogenesis mTOR MDS mechanical unloading AML endothelial function medulloblastoma PKA adipose tissue NAD<sup>+</sup> membranes nutrition ZO-1 TBC1D4 adipocyte soluble Adenylyl cyclase metabolism renin-angiotensin system energy utilization proteasome differentiation signaling peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) hypertrophy AMP-activated protein kinase metabolic disease LKB1 soleus muscle macrophages Immediate early genes CBS benign motor endplate remodeling ionomycin nectin-afadin tight junctions resveratrol protein kinase B regrowth mitochondria protein synthesis energy deficiency catechol-<i>O</i>-methyltransferase fiber-type microarrays carrier acetyl-CoA hypertension 3T3-L1 hypothalamus food intake 3-03897-662-8 Viollet, Benoit auth |
| language |
English |
| format |
eBook |
| author |
Neumann, Dietbert |
| spellingShingle |
Neumann, Dietbert AMP-Activated Protein Kinase Signalling |
| author_facet |
Neumann, Dietbert Viollet, Benoit |
| author_variant |
d n dn |
| author2 |
Viollet, Benoit |
| author2_variant |
b v bv |
| author_sort |
Neumann, Dietbert |
| title |
AMP-Activated Protein Kinase Signalling |
| title_full |
AMP-Activated Protein Kinase Signalling |
| title_fullStr |
AMP-Activated Protein Kinase Signalling |
| title_full_unstemmed |
AMP-Activated Protein Kinase Signalling |
| title_auth |
AMP-Activated Protein Kinase Signalling |
| title_new |
AMP-Activated Protein Kinase Signalling |
| title_sort |
amp-activated protein kinase signalling |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2019 |
| physical |
1 electronic resource (452 p.) |
| isbn |
3-03897-662-8 |
| illustrated |
Not Illustrated |
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AT neumanndietbert ampactivatedproteinkinasesignalling AT violletbenoit ampactivatedproteinkinasesignalling |
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cr |
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noLinkedField |
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