Cellular Mechanisms of Ototoxicity
The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communic...
Saved in:
Superior document: | Frontiers Research Topics |
---|---|
: | |
Year of Publication: | 2018 |
Language: | English |
Series: | Frontiers Research Topics
|
Physical Description: | 1 electronic resource (292 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993543940004498 |
---|---|
ctrlnum |
(CKB)4920000000094279 (oapen)https://directory.doabooks.org/handle/20.500.12854/42869 (EXLCZ)994920000000094279 |
collection |
bib_alma |
record_format |
marc |
spelling |
Carlos Esquivel auth Cellular Mechanisms of Ototoxicity Frontiers Media SA 2018 1 electronic resource (292 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators. The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, move effectively, and remain focused on visual targets during motion. The loss of vestibular sensitivity results in postural instability, falls, inability to observe the environment during motion, and a debilitating incapacity to function effectively. The sensory cells for both auditory and vestibular systems are located within the inner ear of the temporal bulla. There are many causes of auditory and vestibular deficits, including congenital (or genetic) events, trauma, aging and loud sound exposures. Ototoxicity refers to damage of the auditory or vestibular structures or functions, as the result of exposure to certain pharmaceuticals, chemicals, and/or ionizing radiation exposure that damage the inner ear. Ototoxicity is a major contributor to acquired hearing loss and vestibular deficits, and is entirely preventable. In 2009, the United States Department of Defense initiated the Hearing Center of Excellence (HCE), headquartered in San Antonio, Texas, in response to the prevalence of acquired auditory and vestibular deficits in military and veteran populations. The knowledge shared in this eBook supports the HCE’s mandate to improve aural protection of military and civilian populations worldwide. The last few years have seen significant advances in understanding the cellular mechanisms underlying ototoxic drug-induced hearing loss and vestibular deficits. In this eBook, we present some of these advances and highlight gaps where further research is needed. Selected articles discuss candidate otoprotective agents that can ameliorate the effects of ototoxicity in the context of how they illustrate cellular mechanisms of ototoxicity. Our goal in illustrating these advances in mechanisms of ototoxicity is to accelerate the development of clinical therapies that prevent or reverse this debilitating disorder. English blood-labyrinth barrier neurotoxicity otoprotection aminoglycosides ototoxic synergy sensory disorders cisplatin 2-88945-483-5 Kelly Watts auth Peter S. Steyger auth Jian Zuo auth Lisa Cunningham auth |
language |
English |
format |
eBook |
author |
Carlos Esquivel |
spellingShingle |
Carlos Esquivel Cellular Mechanisms of Ototoxicity Frontiers Research Topics |
author_facet |
Carlos Esquivel Kelly Watts Peter S. Steyger Jian Zuo Lisa Cunningham |
author_variant |
c e ce |
author2 |
Kelly Watts Peter S. Steyger Jian Zuo Lisa Cunningham |
author2_variant |
k w kw p s s pss j z jz l c lc |
author_sort |
Carlos Esquivel |
title |
Cellular Mechanisms of Ototoxicity |
title_full |
Cellular Mechanisms of Ototoxicity |
title_fullStr |
Cellular Mechanisms of Ototoxicity |
title_full_unstemmed |
Cellular Mechanisms of Ototoxicity |
title_auth |
Cellular Mechanisms of Ototoxicity |
title_new |
Cellular Mechanisms of Ototoxicity |
title_sort |
cellular mechanisms of ototoxicity |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2018 |
physical |
1 electronic resource (292 p.) |
isbn |
2-88945-483-5 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT carlosesquivel cellularmechanismsofototoxicity AT kellywatts cellularmechanismsofototoxicity AT peterssteyger cellularmechanismsofototoxicity AT jianzuo cellularmechanismsofototoxicity AT lisacunningham cellularmechanismsofototoxicity |
status_str |
n |
ids_txt_mv |
(CKB)4920000000094279 (oapen)https://directory.doabooks.org/handle/20.500.12854/42869 (EXLCZ)994920000000094279 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Cellular Mechanisms of Ototoxicity |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
noLinkedField noLinkedField noLinkedField noLinkedField |
_version_ |
1787548883652444160 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03546nam-a2200397z--4500</leader><controlfield tag="001">993543940004498</controlfield><controlfield tag="005">20231214133458.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202102s2018 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)4920000000094279</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/42869</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)994920000000094279</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Carlos Esquivel</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cellular Mechanisms of Ototoxicity</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2018</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (292 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators. The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, move effectively, and remain focused on visual targets during motion. The loss of vestibular sensitivity results in postural instability, falls, inability to observe the environment during motion, and a debilitating incapacity to function effectively. The sensory cells for both auditory and vestibular systems are located within the inner ear of the temporal bulla. There are many causes of auditory and vestibular deficits, including congenital (or genetic) events, trauma, aging and loud sound exposures. Ototoxicity refers to damage of the auditory or vestibular structures or functions, as the result of exposure to certain pharmaceuticals, chemicals, and/or ionizing radiation exposure that damage the inner ear. Ototoxicity is a major contributor to acquired hearing loss and vestibular deficits, and is entirely preventable. In 2009, the United States Department of Defense initiated the Hearing Center of Excellence (HCE), headquartered in San Antonio, Texas, in response to the prevalence of acquired auditory and vestibular deficits in military and veteran populations. The knowledge shared in this eBook supports the HCE’s mandate to improve aural protection of military and civilian populations worldwide. The last few years have seen significant advances in understanding the cellular mechanisms underlying ototoxic drug-induced hearing loss and vestibular deficits. In this eBook, we present some of these advances and highlight gaps where further research is needed. Selected articles discuss candidate otoprotective agents that can ameliorate the effects of ototoxicity in the context of how they illustrate cellular mechanisms of ototoxicity. Our goal in illustrating these advances in mechanisms of ototoxicity is to accelerate the development of clinical therapies that prevent or reverse this debilitating disorder.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">blood-labyrinth barrier</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">neurotoxicity</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">otoprotection</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">aminoglycosides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">ototoxic synergy</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">sensory disorders</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cisplatin</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88945-483-5</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kelly Watts</subfield><subfield code="4">auth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Peter S. Steyger</subfield><subfield code="4">auth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jian Zuo</subfield><subfield code="4">auth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lisa Cunningham</subfield><subfield code="4">auth</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:55:16 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2019-11-10 04:18:40 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5337544510004498&Force_direct=true</subfield><subfield code="Z">5337544510004498</subfield><subfield code="b">Available</subfield><subfield code="8">5337544510004498</subfield></datafield></record></collection> |