Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease
Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not on...
Saved in:
Superior document: | Frontiers Research Topics |
---|---|
: | |
Year of Publication: | 2016 |
Language: | English |
Series: | Frontiers Research Topics
|
Physical Description: | 1 electronic resource (220 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993543784304498 |
---|---|
ctrlnum |
(CKB)3710000001092140 (oapen)https://directory.doabooks.org/handle/20.500.12854/58607 (EXLCZ)993710000001092140 |
collection |
bib_alma |
record_format |
marc |
spelling |
Pura Munoz-Canoves auth Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease Frontiers Media SA 2016 1 electronic resource (220 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging. English ageing satellite cell pericytes fibrosis myogenesis muscular dystrophies rejuvenation epigenetics muscle wasting sarcopenia 2-88919-866-9 Jaime J. Carvajal auth Adolfo Lopez de Munain auth Ander Izeta auth |
language |
English |
format |
eBook |
author |
Pura Munoz-Canoves |
spellingShingle |
Pura Munoz-Canoves Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease Frontiers Research Topics |
author_facet |
Pura Munoz-Canoves Jaime J. Carvajal Adolfo Lopez de Munain Ander Izeta |
author_variant |
p m c pmc |
author2 |
Jaime J. Carvajal Adolfo Lopez de Munain Ander Izeta |
author2_variant |
j j c jjc a l d m aldm a i ai |
author_sort |
Pura Munoz-Canoves |
title |
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
title_full |
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
title_fullStr |
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
title_full_unstemmed |
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
title_auth |
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
title_new |
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
title_sort |
role of stem cells in skeletal muscle development, regeneration, repair, aging and disease |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2016 |
physical |
1 electronic resource (220 p.) |
isbn |
2-88919-866-9 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT puramunozcanoves roleofstemcellsinskeletalmuscledevelopmentregenerationrepairaginganddisease AT jaimejcarvajal roleofstemcellsinskeletalmuscledevelopmentregenerationrepairaginganddisease AT adolfolopezdemunain roleofstemcellsinskeletalmuscledevelopmentregenerationrepairaginganddisease AT anderizeta roleofstemcellsinskeletalmuscledevelopmentregenerationrepairaginganddisease |
status_str |
n |
ids_txt_mv |
(CKB)3710000001092140 (oapen)https://directory.doabooks.org/handle/20.500.12854/58607 (EXLCZ)993710000001092140 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
noLinkedField noLinkedField noLinkedField |
_version_ |
1796651447922720768 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02928nam-a2200421z--4500</leader><controlfield tag="001">993543784304498</controlfield><controlfield tag="005">20231214132831.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202102s2016 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000001092140</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/58607</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000001092140</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Pura Munoz-Canoves</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2016</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (220 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">ageing</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">satellite cell</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">pericytes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">fibrosis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">myogenesis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">muscular dystrophies</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">rejuvenation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">epigenetics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">muscle wasting</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">sarcopenia</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88919-866-9</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jaime J. Carvajal</subfield><subfield code="4">auth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Adolfo Lopez de Munain</subfield><subfield code="4">auth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ander Izeta</subfield><subfield code="4">auth</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:32:50 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2017-03-11 17:26:08 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5337397850004498&Force_direct=true</subfield><subfield code="Z">5337397850004498</subfield><subfield code="b">Available</subfield><subfield code="8">5337397850004498</subfield></datafield></record></collection> |