Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis
Macrophages comprehend a heterogeneous mononuclear phagocytic population with wide range phenotypes and roles in homeostasis maintenance and diseases, such as infections, autoimmunity and cancer. Technology improvements enable researchers to track different macrophage populations in different tissue...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2017 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (104 p.) |
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Tarcio Teodoro Braga auth Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis Frontiers Media SA 2017 1 electronic resource (104 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Macrophages comprehend a heterogeneous mononuclear phagocytic population with wide range phenotypes and roles in homeostasis maintenance and diseases, such as infections, autoimmunity and cancer. Technology improvements enable researchers to track different macrophage populations in different tissues and situations and hypothesize on their role in promoting inflammation or stimulating tissue repair. Through innate immune recognition system macrophages can launch several effector artilleries that culminate in the production of various types of inflammatory mediators as cytokines, chemokines, lipid mediators and oxygen reactive species, which in turn, influence the behavior of other cells. Furthermore, macrophages and interacting cells are also susceptible to metabolic changes that ultimately will define the outcome macrophage signaling and its effect in the tissue. Here, we present a concise series of discussions on the role of macrophages, its response to the microenvironment and effects on other cells during tissue injury and repair. Triggering of inflammasome in macrophage activation and function is of special interest in this issue. We will emphasize the role of different macrophage subpopulations and the plasticity of these cells during fibrotic process in different models of diseases. English macrophage subtypes inflammation chronic diseases fibrosis 2-88945-332-4 Niels Olsen Saraiva Camara auth Ana Paula Lepique auth Ivan C. Moura auth |
language |
English |
format |
eBook |
author |
Tarcio Teodoro Braga |
spellingShingle |
Tarcio Teodoro Braga Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis Frontiers Research Topics |
author_facet |
Tarcio Teodoro Braga Niels Olsen Saraiva Camara Ana Paula Lepique Ivan C. Moura |
author_variant |
t t b ttb |
author2 |
Niels Olsen Saraiva Camara Ana Paula Lepique Ivan C. Moura |
author2_variant |
n o s c nosc a p l apl i c m icm |
author_sort |
Tarcio Teodoro Braga |
title |
Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
title_full |
Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
title_fullStr |
Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
title_full_unstemmed |
Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
title_auth |
Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
title_new |
Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
title_sort |
macrophages role in integrating tissue signals and biological processes in chronic inflammation and fibrosis |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2017 |
physical |
1 electronic resource (104 p.) |
isbn |
2-88945-332-4 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT tarcioteodorobraga macrophagesroleinintegratingtissuesignalsandbiologicalprocessesinchronicinflammationandfibrosis AT nielsolsensaraivacamara macrophagesroleinintegratingtissuesignalsandbiologicalprocessesinchronicinflammationandfibrosis AT anapaulalepique macrophagesroleinintegratingtissuesignalsandbiologicalprocessesinchronicinflammationandfibrosis AT ivancmoura macrophagesroleinintegratingtissuesignalsandbiologicalprocessesinchronicinflammationandfibrosis |
status_str |
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(CKB)4100000002484698 (oapen)https://directory.doabooks.org/handle/20.500.12854/52534 (EXLCZ)994100000002484698 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
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