Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function / edited by Akira Yoshii, Martha Constantine-Paton and Nancy Y. Ip.
Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways trigg...
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Superior document: | Frontiers Research Topics |
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Place / Publishing House: | France : : Frontiers Media SA,, 2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 online resource (112 pages) :; illustrations. |
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Nancy Y. Ip auth Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function [electronic resource] / edited by Akira Yoshii, Martha Constantine-Paton and Nancy Y. Ip. Frontiers Media SA 2015 France : Frontiers Media SA, 2015 1 online resource (112 pages) : illustrations. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rda Frontiers Research Topics Includes bibliographical references. Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. It is our hope that readers will perceive this volume as a showcase for diversity and complexity of synaptogenic growth factors, and will stimulate further studies in this field. English Molecular biology. netrin neuropsychiatric disease adult neurogenesis FGF7 lipid raft BDNF Leptin Rho GTPase synapse formation FGF22 Akira Yoshii auth Martha Constantine-Paton auth |
language |
English |
format |
Electronic eBook |
author |
Nancy Y. Ip |
spellingShingle |
Nancy Y. Ip Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function Frontiers Research Topics |
author_facet |
Nancy Y. Ip Akira Yoshii Martha Constantine-Paton |
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n y i nyi |
author2 |
Akira Yoshii Martha Constantine-Paton |
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a y ay m c p mcp |
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Nancy Y. Ip |
title |
Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
title_full |
Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function [electronic resource] / edited by Akira Yoshii, Martha Constantine-Paton and Nancy Y. Ip. |
title_fullStr |
Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function [electronic resource] / edited by Akira Yoshii, Martha Constantine-Paton and Nancy Y. Ip. |
title_full_unstemmed |
Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function [electronic resource] / edited by Akira Yoshii, Martha Constantine-Paton and Nancy Y. Ip. |
title_auth |
Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
title_new |
Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
title_sort |
cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (112 pages) : illustrations. |
isbn |
9782889196432 (ebook) |
illustrated |
Illustrated |
work_keys_str_mv |
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status_str |
c |
ids_txt_mv |
(CKB)3710000000824696 (oapen)https://directory.doabooks.org/handle/20.500.12854/42852 (EXLCZ)993710000000824696 |
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hierarchy_parent_title |
Frontiers Research Topics |
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Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
container_title |
Frontiers Research Topics |
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