Transcellular Cycles Underlying Neurotransmission
Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cere...
Saved in:
Superior document: | Frontiers Research Topics |
---|---|
: | |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
|
Physical Description: | 1 electronic resource (105 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993543657304498 |
---|---|
ctrlnum |
(CKB)3710000000824698 (oapen)https://directory.doabooks.org/handle/20.500.12854/61171 (EXLCZ)993710000000824698 |
collection |
bib_alma |
record_format |
marc |
spelling |
Sebastian Cerdan auth Transcellular Cycles Underlying Neurotransmission Frontiers Media SA 2015 1 electronic resource (105 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cerebral activation, neuroglial coupling and the associated neurovascular response. Briefly, exacerbated oxygen consumption in stimulated neurons is thought to trigger glycolytic lactate and glucose transfer from astrocytes which, in turn, obtain these fuels from the microvasculature. Neurotransmitter release is made possible by a combination of transcellular cycles exchanging metabolites between these three compartments, returning eventually the synapsis to its pre-firing situation in the resting periods. In spite of the enormous progresses achieved in recent years, the drivers determining the predominant direction of the fluxes, their quantitative contribution and their energy requirements, have remained until today incompletely understood, more particularly under the circumstances prevailing in vivo. In many instances, progress derived from the implementation of novel methodological approaches including advanced neuroimaging and neurospectroscopy methods. As a consequence, literature in the field became vast, diverse and spread within journals of different specialities. The e-book "Transcellular cycles underlying neurotransmission" aims to summaryze in a single volume, recent progress achieved in hypothesis, methods and interpretations on the trafficking of metabolites between neurons and glial cells, and the associated mechanisms of neurovascular coupling. English Neuroimaging functional MRI Neuroglial metabolic coupling glutamate-glutamine cycle Astrocytic Networks Astrocyte-neuron lactate shuttle 13C NMR Neurovascular coupling 2-88919-654-2 |
language |
English |
format |
eBook |
author |
Sebastian Cerdan |
spellingShingle |
Sebastian Cerdan Transcellular Cycles Underlying Neurotransmission Frontiers Research Topics |
author_facet |
Sebastian Cerdan |
author_variant |
s c sc |
author_sort |
Sebastian Cerdan |
title |
Transcellular Cycles Underlying Neurotransmission |
title_full |
Transcellular Cycles Underlying Neurotransmission |
title_fullStr |
Transcellular Cycles Underlying Neurotransmission |
title_full_unstemmed |
Transcellular Cycles Underlying Neurotransmission |
title_auth |
Transcellular Cycles Underlying Neurotransmission |
title_new |
Transcellular Cycles Underlying Neurotransmission |
title_sort |
transcellular cycles underlying neurotransmission |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2015 |
physical |
1 electronic resource (105 p.) |
isbn |
2-88919-654-2 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT sebastiancerdan transcellularcyclesunderlyingneurotransmission |
status_str |
n |
ids_txt_mv |
(CKB)3710000000824698 (oapen)https://directory.doabooks.org/handle/20.500.12854/61171 (EXLCZ)993710000000824698 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Transcellular Cycles Underlying Neurotransmission |
container_title |
Frontiers Research Topics |
_version_ |
1796648819988889601 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02760nam-a2200361z--4500</leader><controlfield tag="001">993543657304498</controlfield><controlfield tag="005">20231214133048.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202102s2015 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000000824698</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/61171</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000000824698</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Sebastian Cerdan</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Transcellular Cycles Underlying Neurotransmission</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (105 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cerebral activation, neuroglial coupling and the associated neurovascular response. Briefly, exacerbated oxygen consumption in stimulated neurons is thought to trigger glycolytic lactate and glucose transfer from astrocytes which, in turn, obtain these fuels from the microvasculature. Neurotransmitter release is made possible by a combination of transcellular cycles exchanging metabolites between these three compartments, returning eventually the synapsis to its pre-firing situation in the resting periods. In spite of the enormous progresses achieved in recent years, the drivers determining the predominant direction of the fluxes, their quantitative contribution and their energy requirements, have remained until today incompletely understood, more particularly under the circumstances prevailing in vivo. In many instances, progress derived from the implementation of novel methodological approaches including advanced neuroimaging and neurospectroscopy methods. As a consequence, literature in the field became vast, diverse and spread within journals of different specialities. The e-book "Transcellular cycles underlying neurotransmission" aims to summaryze in a single volume, recent progress achieved in hypothesis, methods and interpretations on the trafficking of metabolites between neurons and glial cells, and the associated mechanisms of neurovascular coupling.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Neuroimaging</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">functional MRI</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Neuroglial metabolic coupling</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">glutamate-glutamine cycle</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Astrocytic Networks</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Astrocyte-neuron lactate shuttle</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">13C NMR</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Neurovascular coupling</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88919-654-2</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:41:21 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2016-08-13 16:41:26 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5337409760004498&Force_direct=true</subfield><subfield code="Z">5337409760004498</subfield><subfield code="b">Available</subfield><subfield code="8">5337409760004498</subfield></datafield></record></collection> |