Mysteries of Type I IFN response: benefits versus detriments
Successful containment of an infection is dependent on both innate and adaptive immune response. Cytokines are essential effectors of both of these systems. In particular, type I interferons (IFN-I) are important components of early innate immunity against an infection. However, the production of IF...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Herbert Patrick Ludewick auth Mysteries of Type I IFN response: benefits versus detriments Mysteries of Type I IFN response Frontiers Media SA 2015 1 electronic resource (74 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Successful containment of an infection is dependent on both innate and adaptive immune response. Cytokines are essential effectors of both of these systems. In particular, type I interferons (IFN-I) are important components of early innate immunity against an infection. However, the production of IFN-I could serve as a double edge sword, either containing an infection or enhancing susceptibility. For example, IFN-I, which is essential for early containment of viral infections, has been shown to be detrimental to the host during bacterial infections. In fact, recent significant reports have shown that influenza virus induced IFN-I responses can enhance the host susceptibility to secondary bacterial infections. These recent reports highlight the expanding immunoregulatory role of IFN-I in the host immunity. With these recent findings in mind, the aim of this research topic is to welcome novel data, opinion and literature reviews on the newly identified dual functions of IFN-I. This research topic wills focus on the following areas of IFN-I: 1) a detrimental role of IFN-I during primary bacterial infection; 2) a detrimental role of viral infection induced IFN-I during secondary bacterial infections; 3) evolutionary pressure that drove detrimental IFN-I response during primary bacterial infection; and 4) does benefit of IFN-I responses during primary viral infections outweigh the adverse consequences of IFN-I mediated enhanced susceptibility to secondary bacterial infections. English Autoimmunity adjuvant bacterial and viral infections Vaccine type I IFN 2-88919-629-1 Arno Mullbacher auth Yoichi Furuya auth |
language |
English |
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author |
Herbert Patrick Ludewick |
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Herbert Patrick Ludewick Mysteries of Type I IFN response: benefits versus detriments Frontiers Research Topics |
author_facet |
Herbert Patrick Ludewick Arno Mullbacher Yoichi Furuya |
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h p l hpl |
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Arno Mullbacher Yoichi Furuya |
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Herbert Patrick Ludewick |
title |
Mysteries of Type I IFN response: benefits versus detriments |
title_full |
Mysteries of Type I IFN response: benefits versus detriments |
title_fullStr |
Mysteries of Type I IFN response: benefits versus detriments |
title_full_unstemmed |
Mysteries of Type I IFN response: benefits versus detriments |
title_auth |
Mysteries of Type I IFN response: benefits versus detriments |
title_alt |
Mysteries of Type I IFN response |
title_new |
Mysteries of Type I IFN response: benefits versus detriments |
title_sort |
mysteries of type i ifn response: benefits versus detriments |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2015 |
physical |
1 electronic resource (74 p.) |
isbn |
2-88919-629-1 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT herbertpatrickludewick mysteriesoftypeiifnresponsebenefitsversusdetriments AT arnomullbacher mysteriesoftypeiifnresponsebenefitsversusdetriments AT yoichifuruya mysteriesoftypeiifnresponsebenefitsversusdetriments AT herbertpatrickludewick mysteriesoftypeiifnresponse AT arnomullbacher mysteriesoftypeiifnresponse AT yoichifuruya mysteriesoftypeiifnresponse |
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(CKB)3710000000824729 (oapen)https://directory.doabooks.org/handle/20.500.12854/54188 (EXLCZ)993710000000824729 |
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hierarchy_parent_title |
Frontiers Research Topics |
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Mysteries of Type I IFN response: benefits versus detriments |
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Frontiers Research Topics |
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