BK Channels: Integrators of Cellular Signals in Health and Disease
Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in res...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2017 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (183 p.) |
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Alex Dopico auth BK Channels: Integrators of Cellular Signals in Health and Disease BK Channels Frontiers Media SA 2017 1 electronic resource (183 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Open access Unrestricted online access star Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in response to depolarization and/or increase in local calcium levels. Thus, voltage and calcium ions are involved in gating the channel under physiological conditions. This dual activation makes them perfect sensors for many cellular events that require integration between intracellular calcium levels and electrical signals. A plethora of physiological and pathophysiological functions, such as membrane hyperpolarization, modulation of synaptic transmission, hormone secretion or mental deficiencies, vaso-regulation, epilepsies, heart diseases, myotonic dystrophies, hypertension etc, in almost all cells and tissues were reported for these channels. BK channels are main targets for important ligands like alcohol and gaseous neurotransmitters, such as NO, CO or H2S, to name a few. In the last years, the molecular entities and mechanisms involved in modulation of BK channels have gained tremendous attention, as the key role of these channels in cellular processes became increasingly recognized. Indeed, accessory proteins such as slob, beta and gamma subunits, all serve to modulate the channel gating characteristics. Moreover, channel subunit expression and function is further tuned by phosphorylation/ dephosphorylation processes, redox mechanisms and the lipid microenvironment of the BK channel protein complex. This e-book contains structural and functional aspects of BK channels, channel modulation by a variety of agents and cellular components, as well as the channel’s relevance in health and disease. English BK channel hydrogensulfide maxi calcium activated potassium channel disease nervous system Slo KCNMA1 health ethanol ischemia 2-88945-291-3 Thomas M. Weiger auth Anton Hermann auth |
language |
English |
format |
eBook |
author |
Alex Dopico |
spellingShingle |
Alex Dopico BK Channels: Integrators of Cellular Signals in Health and Disease Frontiers Research Topics |
author_facet |
Alex Dopico Thomas M. Weiger Anton Hermann |
author_variant |
a d ad |
author2 |
Thomas M. Weiger Anton Hermann |
author2_variant |
t m w tmw a h ah |
author_sort |
Alex Dopico |
title |
BK Channels: Integrators of Cellular Signals in Health and Disease |
title_full |
BK Channels: Integrators of Cellular Signals in Health and Disease |
title_fullStr |
BK Channels: Integrators of Cellular Signals in Health and Disease |
title_full_unstemmed |
BK Channels: Integrators of Cellular Signals in Health and Disease |
title_auth |
BK Channels: Integrators of Cellular Signals in Health and Disease |
title_alt |
BK Channels |
title_new |
BK Channels: Integrators of Cellular Signals in Health and Disease |
title_sort |
bk channels: integrators of cellular signals in health and disease |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2017 |
physical |
1 electronic resource (183 p.) |
isbn |
2-88945-291-3 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT alexdopico bkchannelsintegratorsofcellularsignalsinhealthanddisease AT thomasmweiger bkchannelsintegratorsofcellularsignalsinhealthanddisease AT antonhermann bkchannelsintegratorsofcellularsignalsinhealthanddisease AT alexdopico bkchannels AT thomasmweiger bkchannels AT antonhermann bkchannels |
status_str |
n |
ids_txt_mv |
(CKB)4100000002484689 (oapen)https://directory.doabooks.org/handle/20.500.12854/42315 (EXLCZ)994100000002484689 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
BK Channels: Integrators of Cellular Signals in Health and Disease |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
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