Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic
The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of dise...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2017 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (220 p.) |
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Olivier Darbin auth Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic Pathophysiology of the Basal Ganglia and Movement Disorders Frontiers Media SA 2017 1 electronic resource (220 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders. English Braak's hypothesis basal ganglia Parkinson's disease cycling movement disorders computational modeling Huntington's disease non-motor symptoms nonlinear dynamics deep brain stimulation 2-88945-317-0 Daniela Andres auth Marcelo Merello auth |
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English |
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author |
Olivier Darbin |
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Olivier Darbin Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic Frontiers Research Topics |
author_facet |
Olivier Darbin Daniela Andres Marcelo Merello |
author_variant |
o d od |
author2 |
Daniela Andres Marcelo Merello |
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Olivier Darbin |
title |
Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
title_full |
Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
title_fullStr |
Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
title_full_unstemmed |
Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
title_auth |
Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
title_alt |
Pathophysiology of the Basal Ganglia and Movement Disorders |
title_new |
Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
title_sort |
pathophysiology of the basal ganglia and movement disorders: gaining new insights from modeling and experimentation to influence the clinic |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2017 |
physical |
1 electronic resource (220 p.) |
isbn |
2-88945-317-0 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT olivierdarbin pathophysiologyofthebasalgangliaandmovementdisordersgainingnewinsightsfrommodelingandexperimentationtoinfluencetheclinic AT danielaandres pathophysiologyofthebasalgangliaandmovementdisordersgainingnewinsightsfrommodelingandexperimentationtoinfluencetheclinic AT marcelomerello pathophysiologyofthebasalgangliaandmovementdisordersgainingnewinsightsfrommodelingandexperimentationtoinfluencetheclinic AT olivierdarbin pathophysiologyofthebasalgangliaandmovementdisorders AT danielaandres pathophysiologyofthebasalgangliaandmovementdisorders AT marcelomerello pathophysiologyofthebasalgangliaandmovementdisorders |
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(CKB)4100000002484711 (oapen)https://directory.doabooks.org/handle/20.500.12854/55792 (EXLCZ)994100000002484711 |
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Frontiers Research Topics |
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Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
container_title |
Frontiers Research Topics |
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