Aging, neurogenesis and neuroinflammation in hearing loss and protection / / Marta Magariños, Marta Milo and Isabel Varela-Nieto.
Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when...
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Place / Publishing House: | [Lausanne, Switzerland] : : Frontiers Media SA,, [2015] ©2015 |
Year of Publication: | 2015 |
Language: | English |
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Physical Description: | 1 online resource (151 pages) :; illustrations (chiefly colour); digital file(s). |
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Marta Magarinos auth Aging, neurogenesis and neuroinflammation in hearing loss and protection / Marta Magariños, Marta Milo and Isabel Varela-Nieto. Frontiers Media SA 2015 [Lausanne, Switzerland] : Frontiers Media SA, [2015] ©2015 1 online resource (151 pages) : illustrations (chiefly colour); digital file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rda Frontiers Research Topics Includes bibliographical references. Open access Unrestricted online access star Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies.There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease.In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes involved in ageing as senescence and autophagy, to molecules essential for hearing as IGF-1 and neurotrophins. Neuroinflammation takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Neurogenesis is also essential to understand the adult cochlea self-repair potential. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies. Also available in print form. In English. Description based on e-publication, viewed June 12, 2020. Presbycusis. Vestibular apparatus. Deafness Etiology. Deafness Treatment. TGF-beta Noise Hair cells redox balance spiral ganglion neurons Drug delivery ARHL Auditory Cortex Lipid homeostasis Inner ear Magariños, Marta, editor, contributor. Milo, Marta, editor, contributor. Varela-Nieto, Isabel, editor, contributor. Frontiers in Aging Neuroscience Print version: 2889196445 Frontiers research topics. |
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Marta Magarinos |
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Marta Magarinos Aging, neurogenesis and neuroinflammation in hearing loss and protection / Frontiers Research Topics |
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Marta Magarinos Magariños, Marta, Milo, Marta, Varela-Nieto, Isabel, |
author_variant |
m m mm |
author2 |
Magariños, Marta, Milo, Marta, Varela-Nieto, Isabel, |
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m m mm m m mm m m mm i v n ivn |
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TeilnehmendeR TeilnehmendeR TeilnehmendeR |
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Marta Magarinos |
title |
Aging, neurogenesis and neuroinflammation in hearing loss and protection / |
title_full |
Aging, neurogenesis and neuroinflammation in hearing loss and protection / Marta Magariños, Marta Milo and Isabel Varela-Nieto. |
title_fullStr |
Aging, neurogenesis and neuroinflammation in hearing loss and protection / Marta Magariños, Marta Milo and Isabel Varela-Nieto. |
title_full_unstemmed |
Aging, neurogenesis and neuroinflammation in hearing loss and protection / Marta Magariños, Marta Milo and Isabel Varela-Nieto. |
title_auth |
Aging, neurogenesis and neuroinflammation in hearing loss and protection / |
title_new |
Aging, neurogenesis and neuroinflammation in hearing loss and protection / |
title_sort |
aging, neurogenesis and neuroinflammation in hearing loss and protection / |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (151 pages) : illustrations (chiefly colour); digital file(s). Also available in print form. |
isbn |
9782889196449 2889196445 |
illustrated |
Illustrated |
dewey-hundreds |
600 - Technology |
dewey-tens |
610 - Medicine & health |
dewey-ones |
617 - Surgery & related medical specialties |
dewey-full |
617.8 |
dewey-sort |
3617.8 |
dewey-raw |
617.8 |
dewey-search |
617.8 |
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Aging, neurogenesis and neuroinflammation in hearing loss and protection / |
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