Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology
The complexity of living organisms surpasses our unaided habilities of analysis. Hence, computational and mathematical methods are necessary for increasing our understanding of biological systems. At the same time, there has been a phenomenal recent progress allowing the application of novel formal...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2016 |
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David A. Rosenblueth auth Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology Computational Methods for Understanding Complexity Frontiers Media SA 2016 1 electronic resource (111 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics The complexity of living organisms surpasses our unaided habilities of analysis. Hence, computational and mathematical methods are necessary for increasing our understanding of biological systems. At the same time, there has been a phenomenal recent progress allowing the application of novel formal methods to new domains. This progress has spurred a conspicuous optimism in computational biology. This optimism, in turn, has promoted a rapid increase in collaboration between specialists of biology with specialists of computer science. Through sheer complexity, however, many important biological problems are at present intractable, and it is not clear whether we will ever be able to solve such problems. We are in the process of learning what kind of model and what kind of analysis and synthesis techniques to use for a particular problem. Some existing formalisms have been readily used in biological problems, others have been adapted to biological needs, and still others have been especially developed for biological systems. This Research Topic has examples of cases (1) employing existing methods, (2) adapting methods to biology, and (3) developing new methods. We can also see discrete and Boolean models, and the use of both simulators and model checkers. Synthesis is exemplified by manual and by machine-learning methods. We hope that the articles collected in this Research Topic will stimulate new research. English model checking Logic programing Answer set programing attractors of Boolean networks synthesis of biochemical models Gene Regulatory Networks Boolean networks biochemical networks 2-88945-042-2 |
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English |
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David A. Rosenblueth |
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David A. Rosenblueth Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology Frontiers Research Topics |
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David A. Rosenblueth |
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d a r dar |
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David A. Rosenblueth |
title |
Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology |
title_full |
Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology |
title_fullStr |
Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology |
title_full_unstemmed |
Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology |
title_auth |
Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology |
title_alt |
Computational Methods for Understanding Complexity |
title_new |
Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology |
title_sort |
computational methods for understanding complexity: the use of formal methods in biology |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
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Frontiers Media SA |
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2016 |
physical |
1 electronic resource (111 p.) |
isbn |
2-88945-042-2 |
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Not Illustrated |
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AT davidarosenblueth computationalmethodsforunderstandingcomplexitytheuseofformalmethodsinbiology AT davidarosenblueth computationalmethodsforunderstandingcomplexity |
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(CKB)4100000002484628 (oapen)https://directory.doabooks.org/handle/20.500.12854/43706 (EXLCZ)994100000002484628 |
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Frontiers Research Topics |
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Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology |
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Frontiers Research Topics |
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