Cysteine Proteinases and their Inhibitors : : Proceedings of the International Symposium Portoroz, Yugoslavia, September 15–18, 1985 / / ed. by Vito Turk.
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Other title: | Frontmatter -- PREFACE -- ACKNOWLEDGEMENT -- ORGANIZING COMMITTEE -- CONTENTS -- NOMENCLATURE AND CLASSIFICATION OF THE PROTEINS HOMOLOGOUS WITH THE CYSTEINE PROTEINASE INHIBITOR CHICKEN CYSTATIN -- GENERAL CYSTEINE PROTEINASES -- Isolation, properties , primary structure and cloning -- Human cathepsins B, H and L: characterization by amino acid sequences and some kinetics of inhibition by the kininogens -- Tentative amino acid sequence of bovine spleen cathepsin B -- Inhibition of human liver cathepsins B, H and L by the human α2 cysteine proteinase inhibitor -- Human kidney cathepsin L -- Latent human cathepsin L -- Cloning of a bovine protein homologous with cysteine proteinases and identification of the gene -- Immunological studies on the secreted forms of cathepsin B -- A study of the peptidyldipeptidase activity of bovine spleen cathepsin B using synthetic substrates -- Comparison of characteristics and drug-induced modifications of rat spleen cathepsins B and H -- Cystein proteinase activities in embryonic chicken sekeletal muscle -- Histone degradation by lysosomal proteases -- Properties of a cysteine proteinase from human thyroids -- Primary structure and function of calcium activated neutralprotease -- Identification of two alkaline cysteine proteinases from rat skeletal muscle -- Multiple forms, structure and specificity of clostripain -- Enzymatic and immunological identification of a cysteine proteinase procoagulant in human melanoma -- Thyroid cysteine proteinases that catalyze release of thyroxine from thyroglobulin and thyroxine-containing peptide -- Proteases in African trypanosomes -- Characterization of a cysteinyl proteinase from the human parasite, Schistosoma mansoni -- Studies on a proteinase inactivating enzyme from the basidiomycete Coprinus atramentarius -- GENERAL CYSTEINE PROTEINASES OF DIFFERENT ORIGIN -- Localization and biological role -- Distributions and localizations of lysosomal cysteine proteinases and cystatins -- Functional shares of cathepsins B, H and L in autophagy and heterophagy -- Post mortem localization of lysosomal peptide hydrolase, cathepsin B -- Bifunctional derivatives of L-trans-epoxysuccinyl-L- -leucylamido-(4-amino)butane (Ep-459) as potential localization agents for cysteine proteinases -- Cysteine proteinases and bone resorption -- The role of collagen-degrading cysteine proteinases in connective tissue metabolism -- The role of cathepsins H and B, and inhibitors leupeptin and CPI in proliferative activities of non-malignant cells in culture -- Viruses as vectors for cysteine proteases -- MECHANISM OF ACTION OF CYSTEINE PROTEINASES -- Natural structural variation in the cysteine proteinases as an aid to the study of mechanism by reactivity probe kinetics, catalysis kinetics and spectroscopic methods -- Mechanism of action of cysteine proteases: 1/ differences from serine enzymes;2/ the second thiol group of chymopapain -- Proposal of the double regulation mechanism for the action of calpain -- Control mechanism of calcium-activated neutral protease (CANP) activity -- GENERAL CYSTEINE PROTEINASE INHIBITORS -- Isolation, properties and primary structure -- The mammalian cysteine proteinase inhibitors. Structural diversity and evolutionary origin -- Kininogens as thiol proteinase inhibitors -- Cystatin-like domains of LMW-kininogen, and speculations on the evolution of cystatins -- Human stefins and cystatins: their properties and structural relationships -- Isolation of kininogens using affinity chromatography -- Characterization of low molecular mass cysteine proteinase inhibitors from human amniotic fluid -- Properties and structure of human spleen stefin B - a low molecular weight protein inhibitor of cysteine proteinases -- Amino acid sequence of the cysteine proteinase inhibitor cystatin B from human liver -- Cystatin S and the related cysteine proteinase inhibitors in human saliva -- Cystatin C (Post γ Globulin) in serum from patients with autoimmune diseases -- Differential actions of human cystatin C on different functions of granulocytes -- Potentiation of excretion of canine cystatin-C (Post-gamma globulin) -- The 43 kDa papain inhibitor in human tissues -- Small and high molecular weight proteinase inhibitors from bovine muscle -- Low molecular weight protein inhibitors of cysteine proteinases from bovine parotid glands -- The interaction of papain molecule with thiol proteinase inhibitors from newborn rat epidermis -- Chicken egg white cystatin as a ligand for affinity chromatography -- Distribution of the egg white cystatin in chicken -- Isolation and characterization of chicken egg white low-Mr kininogen -- Papain inhibition by snake venoms -- Cysteine proteinase inhibitors from fish liver -- Cysteine proteinase inhibitors from sea anemone -- Characterization of low molecular weight and high molecular weight endogenous inhibitors of calcium activated neutral protease -- Calpain inhibition by peptide epoxides and the effect of autolysis -- EST, a new analog of E-64, can prolong the life span of dystrophic hamsters, UM-X7.1 -- Localization, biological function and kinetics -- Cystatins A and B in normal and pathologically altered human tissues -- Chicken and rat muscle cystatins and their localization in cultured myoblasts -- Distribution and solubilization of a high molecular weight cysteine proteinase inhibitor from rat epidermis -- Possible biological functions of protein proteinase inhibitors -- A curve-fitting approach to the determination of kinetic constants of proteinase inhibitors -- Inhibition of cathepsins B, H and L by rat thiostatin, the circulating α1 cysteine proteinase inhibitor, and by an active fragment -- CYSTEINE PROTEINASES AND THEIR INHIBITORS IN TUMORS -- Tumor cysteine proteinases and their inhibitors -- Thiol protease inhibitor released from human malignant melanoma -- PROTEINASES AND THEIR INHIBITORS -- Medical aspects -- Cystatin C (α-trace) amyloidosis -- Some biochemical aspects of chymopapain treatment of sciatica -- Granulocyte proteinases as mediators of unspecific proteolysis in inflammation: a review -- LIST OF PARTICIPANTS -- AUTHOR INDEX -- SUBJECT INDEX -- Backmatter |
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Format: | Mode of access: Internet via World Wide Web. |
ISBN: | 9783110846836 9783110637342 |
DOI: | 10.1515/9783110846836 |
Access: | restricted access |
Hierarchical level: | Monograph |
Statement of Responsibility: | ed. by Vito Turk. |
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