Optogenetics / / ed. by Peter Hegemann, Stephan Sigrist.

• Superior document: Title is part of eBook package: De Gruyter DGBA Backlist Complete English Language 2000-2014 PART1
• MitwirkendeR: Baier, Herwig,; Beck, Heinz,; Bono, Mario de,; Boyden, Edward S.,; Deisseroth, Karl,; Eban-Rothschild, Ada,; Fenno, Lief E.,; Fiala, André,; Gottschalk, Alexander,; Gradinaru, Viviana,; Hahn, Klaus,; Helmchen, Fritjof,; Häusser, Michael,; Isacoff, Ehud Y.,; Jørgensen, Erik M.,; Kaupp, Benjamin,; Knöpfel, Thomas,; Konnerth, Arthur,; Kramer, Richard H.,; Kubo, Fumi,; Labella, Matt L.,; Lecea, Luis de,; Lorenz, Birgit,; Miesenböck, Gero,; Moffat, Keith,; Moser, Tobias,; Möglich, Andreas,; Müller, Sabine,; Oertner, Thomas G.,; Pan, Zhuo-Hua,; Roska, Botond,; Sahel, José-Alain,; Schafer, William R.,; Schleiermacher, Sabine,; Sigrist, Stephan,; Sturm, V.,; Touriño, Clara,; Trauner, Dirk,; Walter, Henrik,; Yawo, Hiromu,; Zalocusky, Kelly A.,; Zhang, Feng,; Zrenner, Eberhart,
• HerausgeberIn: Hegemann, Peter,; Sigrist, Stephan,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2013]; ©2013
• Year of Publication: 2013
• Language: English
• Series: Dahlem Workshop Reports ,
• Physical Description: 1 online resource (226 p.)

Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and Restoration of vision and hearing. The concept and content was developed with top international researchers and students at a prestigious Dahlem Conference workshop.

Table of Contents

Frontmatter -- Content -- Introduction -- 1 The biophysics and engineering of signaling photoreceptors -- 2 Current challenges in optogenetics -- 3 Challenges and opportunities for optochemical genetics -- 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives -- 5 Why optogenetic “control” is not (yet) control -- 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans -- 7 Putting genetics into optogenetics: knocking out proteins with light -- 8 Optogenetic approaches in behavioral neuroscience -- 9 Combining genetic targeting and optical stimulation for circuit dissection in the zebrafish nervous system -- 10 Optogenetic analysis of mammalian neural circuits -- 11 Optogenetics to benefit human health: opportunities and challenges -- 12 Optogenetic tools for controlling neural activity: molecules and hardware -- 13 In vivo application of optogenetics in rodents -- 14 Potential of optogenetics in deep brain stimulation -- 15 Optogenetic approaches for vision restoration -- 16 Restoration of vision – the various approaches -- 17 Optogenetic approaches to cochlear prosthetics for hearing restoration -- 18 History in the making: the ethics of optogenetics -- 19 Optogenetics as a new therapeutic tool in medicine? A view from the principles of biomedical ethics -- Appendix -- Index