Kallikrein-related peptidases. / Volume 1, : Characterization, regulation, and interactions within the protease web / / ed. by Viktor Magdolen.

• Superior document: Title is part of eBook package: De Gruyter DGBA Backlist Complete English Language 2000-2014 PART1
• MitwirkendeR: Batra, Jyotsna,; Bayani, Jane,; Beaufort, Nathalie,; Becker-Pauly, Christoph,; Bhoola, Kanti D.,; Bode, Wolfram,; Brattsand, Maria,; Clements, Judith A.,; Craik, Charles S.,; Cretu, Daniela,; Darmoul, Dalila,; Debela, Mekdes,; Deperthes, David,; Diamandis, Eleftherios P.,; Dimitromanolakis, Apostolos,; Emami, Nashmil,; Faussner, Alexander,; Figueroa, Carlos D.,; Fritz, Hans,; Goettig, Peter,; Harris, Jonathan M.,; Hollenberg, Morley D.,; Hooper, John D.,; Hu, Jan C.C.,; Hu, Yuanyuan,; Kündig, Christoph,; LeBeau, Aaron M.,; Lose, Felicity,; Lundwall, Åke,; Magdolen, Viktor,; Milou, Valentina,; Oikonomopoulou, Katerina,; O’Mara, Tracy,; Petraki, Constantina D.,; Richardson, Amelia S.,; Scarisbrick, Isobel A.,; Schmitt, Manfred,; Scorilas, Andreas,; Simmer, James P.,; Sommerhoff, Christian P.,; Swedberg, Joakim E.,; Veer, Simon J. De,; Yousef, George M.,
• HerausgeberIn: Fritz, Hans,; Magdolen, Viktor,; Schmitt, Manfred,; Sommerhoff, Christian P.,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2012]; ©2013
• Year of Publication: 2012
• Language: English
• Series: Kallikrein-related peptidases ; Volume 1
• Physical Description: 1 online resource (409 p.)
• Other title: Frontmatter --; Preface --; List of contributing authors --; Table of Contents --; Introduction to Volume 1: Kallikrein-related Peptidases. Characterization, Regulation, and Interactions Within the Protease Web --; 1 Genomic Structure of the KLK Locus --; 2 Single Nucleotide Polymorphisms in the Human KLK Locus and Their Implication in Various Diseases --; 3 Evolution of Kallikrein-related Peptidases --; 4 Structural Aspects of Kallikrein-related Peptidases --; 5 Molecular Recognition Properties of Kallikrein-related Peptidases on Synthetic and Endogenous Substrates --; 6 Natural, Engineered and Synthetic Inhibitors of Kallikrein-related Peptidases --; 7 Kallikrein-related Peptidases as Pharmaceutical Targets --; 8 Expression of Kallikrein-related Peptidases under (Patho-)Physiological Conditions --; 9 Kallikrein-related Peptidases within the Proteolytic Web --; 10 Kallikrein-Kinin Cascade: Bioregulation by Human Tissue Kallikrein 1 (hK1, KLK1) --; 11 Role of KLK4 in Dental Enamel Formation --; 12 Kallikrein-related Peptidases and Semen --; 13 Kallikrein-related Peptidases and Inhibitors of the Skin --; 14 Physiological and Pathophysiological Roles of Kallikrein-related Peptidases in the Central Nervous System --; 15 Kallikrein-related Peptidases (KLKs), Proteinase-mediated Signaling and Proteinase-activated Receptors (PARs) --; Index
• Format: Mode of access: Internet via World Wide Web.
• ISBN: 9783110260373; 9783110238570; 9783110238495; 9783110637915; 9783110288995; 9783110294071; 9783110294064
• DOI: 10.1515/9783110260373
• Access: restricted access
• Hierarchical level: Monograph
• Statement of Responsibility: ed. by Viktor Magdolen.

This handbook is the first comprehensive book of its kind reviewing the clinically relevant current status of tissue kallikrein and kallikrein-related peptidases research. Since several members of the KLK family are key players in (patho-)physiological processes, structural, functional, and regulatory studies are under way to develop new strategies to prevent and treat disorders to which individual members of the KLK protease family contribute significantly. The goal of this book is to inform clinicians, physician scientists and researchers about the prominent role of the multifaceted and interactive KLK system in normal physiology and pathological organ function.