In Vitro and In Vivo Hemolysis : : An Unresolved Dispute in Laboratory Medicine / / Giuseppe Lippi, Emmanuel J. Favaloro, Mario Plebani, Gianfranco Cervellin.

• Superior document: Title is part of eBook package: De Gruyter DGBA Backlist Complete English Language 2000-2014 PART1
• VerfasserIn: Lippi, Giuseppe,; Cervellin, Gianfranco,; Favaloro, Emmanuel J.,; Plebani, Mario,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2012]; ©2012
• Year of Publication: 2012
• Language: English
• Series: Patient Safety ; 4
• Physical Description: 1 online resource (102 p.)

Defined as red blood cell break down and the release of hemoglobin and intracellular contents into the plasma, hemolysis can seriously impact patient care as well as the laboratory's reputation through its affect on test results. Therefore, the European Preanalytical Scientific Committee, in collaboration with the International Federation of Clinical Chemistry Working Group on Patient Safety, have designed a questionnaire to collect data on prevalence and management of hemolytic specimens referred to the clinical laboratories for clinical chemistry testing. This book will help identify the areas where hemolysis occurs most frequently, which can, in turn, guide further analysis about why it is occurring. Once these elements are known, practices and procedures can be implemented to dramatically reduce hemolysis and avoid erroneous laboratory results affecting patient care and increasing laboratory costs.

Table of Contents

Frontmatter -- Contents -- Preface -- 1 Structure and function of red blood cells -- 2 Red blood cell parameters -- 3 Definition of hemolysis -- 4 Prevalence of hemolyzed specimens in clinical laboratories -- 5 In vivo hemolysis -- 6 In vitro hemolysis -- 7 How to distinguish in vivo versus in vitro hemolysis -- 8 Effects of in vitro hemolysis on laboratory testing -- 9 Spurious hemolysis and veterinary medicine -- 10 Detection of hemolyzed specimens -- 11 Management of hemolyzed specimens -- 12 The challenge of synthetic blood substitutes -- References -- Index