Prions in Humans and Animals / / ed. by Beat Hörnlimann, Detlev Riesner, Hans A. Kretzschmar.
Dieses umfassende Werk in englischer Sprache richtet sich gleichermaßen an Studenten und Forscher. Es behandelt systematisch alle Aspekte der Prionenkrankheiten, von ihrer Geschichte, Mikrobiologie und Pathologie bis hin zu Übertragungswegen und möglicher Prävention. Das Buch beschreibt Krankheiten...
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Table of Contents:
- Frontmatter
- Table of Contents
- Abbreviations
- Topic I: History
- 1. Historical Introduction
- 2. History of Kuru Research
- 3. History of Prion Research
- Topic II: Molecular Biology and Genetics
- 4. The Physical Nature of the Prion
- 5. Folding of the Recombinant Prion Protein
- 6. Structural Studies of Prion Proteins
- 7. Function of Cellular Prion Protein (PrPC) in Copper Homeostasis and Redox Signaling at the Synapse
- 8. The Scarpie Isoform of the Prion Protein PrPSe Compared to the Celluar Isoform PrPC
- 9. The Phylogeny of Mammalian and Nonmammalian Prion Proteins
- 10. Knockouts and Transgenic Mice in Prion Research
- 11. Transplantation as a Tool in Prion Research
- 12. Prion Strains
- Topic III: Portraits of Prion Diseases
- 13. Portrait of Kuru
- 14. Portrait of Creutzfeldt-Jakob Disease
- 15. Portrait of Variant Creutzfeldt-Jakob Disease
- 16. Portrait of Gerstmann-Sträussler-Scheinker Disease
- 17. Portrait of Fatal Familial Insomnia and Sporadic Fatal Insomnia
- 18. Portrait of Scrapie in Sheep and Goat
- 19. Portrait of Bovine Spongiform Encephalopathy in Cattle and Other Ungulates
- 20. Portrait of Prion Diseases in Zoo Animals
- 21. Portrait of Chronic Wasting Disease in Deer Species
- 22. Portrait of Transmissible Mink Encephalopathy
- 23. Portrait of Transmissible Feline Spongiform Encephalopathy
- 24. Portrait of Experimental BSE in Pigs
- 25. Portrait of a Spongiform Encephalopathy in Birds and the Transmissibility of Mammalian Prior Diseases to Birds
- Topic IV: Pathology
- 26. Pathology and Genetics of Human Prion Diseases
- 27. The Pathology of Prion Diseases in Animals
- 28. Pathophysiology of Prion Diseases Following Peripheral Infection
- Topic V: Surveillance, Clinical Aspects and Diagnostics
- 29. Introduction of Surveillance for Human Prion Diseases
- 30. Clinical Findings in Human Prion Diseases
- 31. Methods for the Clinical Diagnosis of Human Prion Deseases
- 32. Introduction to Surveillance for Animal Prion Diseases
- 33. Clinical Findings in Bovine Spongiform Encephalopathy
- 34. Clinical Findings in Scrapie
- 35. Diagnosis of Bovine Spongiform Encephalopathy by Immunological Methods
- Topic VI: Epidemiology
- 36. Epidemiology and Risk Factors of Creutzfeldt-Jakob Disease
- 37. Creutzfeldt-Jakob Disease in Germany
- 38. The Epidemiology of Kuru
- 39. The Course of the BSE Epidemic - Retrospective Epidemiological Considerations
- 40. The Causes of the BSE Epidemic
- Topic VII: Transmissibility
- 41. The Experimental Transmissibility of Prions and Infectivity Distribution in the Body
- 42. Iatrogenic and "Natural" Transmissibility of Prion Diseases
- Topic VIII: Agent Inactivation
- 43. Inactivation in Practice - Risk Assessment and Validation for Food Gelatin
- 44. Chemical Disinfection and Inactivation of Prions
- 45. Thermal Inactivation of Prions
- Topic IX: Prevention
- 46. Prevention of Prion Diseases in the Production of Medicinal Products, Medical Devices, and Cosmetics
- 47. Prevention of the Transmission of Prion Diseases in Healthcare Settings
- 48. Precautionary Measures for Autopsies Performed in Cases of Suspected Prion Disease
- 49. Prevention of Prion Diseases in Research Laboratories
- Topic X: Risk Assessment
- 50. Evidence for a Link between Variant Creutzfeldt-Jakob Disease and Bovine Spongiform Encephalopathy
- 51. Risk Assessment of Transmitting Prion Diseases through Blood, Cornea, and Dura Mater
- 52. BSE Risk Assessment and Minimization
- 53. BSE Control - Internationally Recommended Approaches
- 54. Atypical Scrapie-Nor98
- 55. Scrapie Control - Internationally Recommended Approaches
- 56. The PrP Genotype as a Marker for Scrapie Susceptibility in Sheep
- 57. Scrapie control at the National level: The Norwegian Example
- Backmatter
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