Fifty Years of Genetic Load : : An Odyssey / / Bruce Wallace.

• Superior document: Title is part of eBook package: De Gruyter Cornell University Press Archive Pre-2000
• VerfasserIn: Wallace, Bruce,
• Place / Publishing House: Ithaca, NY : : Cornell University Press, , [2019]; ©1991
• Year of Publication: 2019
• Language: English
• Physical Description: 1 online resource (192 p.)

In this personal history, one of the pioneers in population genetics recounts the evolution of his ideas about the effects of genetic variability on a population. Tracing the results of successive experiments over the years, it is, like the author's career, highly original.Bruce Wallace's book is the odyssey of a man whose concern has always been the posing and answering of research questions. Its span extends from a simple attempt to verify some mathematical calculations to a statement of what he considers to be a definitive experiment bearing on current neutralist-selectionist disagreements. "The account proceeds," he writes, "from my Cornell University acceptance that a load (genetic or phenotypic) harms a population, to a later belief that it has little or no bearing on a population's well-being, and, then, to my present feeling that a phenotypic load (which may or may not have a genetic basis) provides the means for culling of excess individuals, thus avoiding overcrowding and increasing the probability that a population will persist through time."A solid contribution to our understanding of modern population genetics, this book will be of interest to evolutionary and population biologists, ecologists, and historians and philosophers of science.

Table of Contents

Frontmatter -- CONTENTS -- PREFACE -- 1. INTRODUCTION -- 2. GENETIC VARIATION, DARWINIAN FITNESS, AND GENETIC LOAD -- 3. STUDIES OF IRRADIATED POPULATIONS -- 4. RANDOM MUTATIONS AND VIABILITY -- 5. DILEMMAS AND OPTIONS -- 6. HARD AND SOFT SELECTION -- 7. PERSISTENCE: AN IMPORTANT COMPONENT OF POPULATION FITNESS -- 8. SELF-CULLING AND THE PERSISTENCE OF POPULATIONS -- 9. SUMMARIZING REMARKS -- 10. STILL TO COME ... -- REFERENCES -- INDEX