Essays in Biochemistry, Volume 33 : : Molecular Biology of the Brain / / ed. by S. J. Higgins.

• MitwirkendeR: Budd, Samantha L.,; Caroni, Pico,; Greenfield, Susan,; Haley, Jane E.,; Hardy, John,; Higgins, Steve,; Huang, Emily P.,; Hutton, Michael,; Kieffer, Brigitte L.,; Lancet, Doron,; Lunkes, Astrid,; Mandel, Jean-Louis,; Massotte, Dominique,; Nicholls, David G.,; Perez-Tur, Jordi,; Pilpel, Yitzhak,; Sehiavo, Giampietro,; Sosinsky, Alona,; Stenbeck, Gudrun,; Stevens, Charles F.,; Strange, Philip G.,; Tear, Guy,; Trottier, Yvon,; Wheatley, Mark,
• HerausgeberIn: Higgins, S. J.,
• Place / Publishing House: Princeton, NJ : : Princeton University Press, , [2017]; ©1999
• Year of Publication: 2017
• Language: English
• Series: Princeton Legacy Library ; 5151
• Physical Description: 1 online resource (198 p.)

The workings of the brain have long held a fascination for scientists. Yet, faced as they have been with the obvious anatomical and biochemical complexity of the brain, understanding its functions--more than superficially--has seemed an impossible goal. The authors of the essays in this volume, acknowledged experts in their specialties, have illustrated the power of molecular biology to dissect the molecular functioning of the brain. The volume has related essays on neurotransmitters and their receptors, aspects of neuronal development and neurodegeneration, the molecular biology of opiate action, and the concept of neuronal networks in the olfactory system. It continues with essays on some of the major healthcare problems that can be expected to yield to analysis by molecular genetical approaches--neurodegenerative and affective disorders such as schizophrenia, Alzheimer's disease, spongiform encephalopathies, prion diseases, and trinucleotide expansion disorders. The volume concludes first with an exciting account of how molecular biology is beginning to explain a phenomenon as complex as memory and, finally, a thought-provoking essay on future developments in the field.Originally published in 1999.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Table of Contents

Frontmatter -- Contents -- Preface -- Authors -- Abbreviations -- 1. Molecular cues that guide the development of neural connectivity -- 2. Understanding neurotransmitter receptors: molecular biology-based strategies -- 3. Molecular analysis of neurotransmitter release -- 4. Mitochondria in the life and death of neurons -- 5. Neuro-regeneration: plasticity for repair and adaptation -- 6. A molecular basis for opiate action -- 7. Gases as neurotransmitters -- 8. Molecular biology of olfactory receptors -- 9. Pathology and drug action in schizophrenia: insights from molecular biology -- 10. Genetics of Alzheimer's disease -- 11. Use of brain grafts to study the pathogenesis of prion diseases -- 12. Pathological mechanisms in Huntington's disease and other polyglutamine expansion diseases -- 13. The matter of mind: molecular control of memory -- 14. Future developments -- Subject index