Cellular Responses to Stress / / ed. by C. P. Downes, D. P. Lane, C. R. Wolf.

• Superior document: Title is part of eBook package: De Gruyter Princeton Legacy Lib. eBook Package 1980-1999
• MitwirkendeR: Brown, K.,; Cotto, Jose J.,; Davis, Roger J.,; Dean, Jon,; Demple, Bruce,; Ding, Huangen,; Divecha, Nullin,; Ellis, Elizabeth M.,; Finch, Andrew,; Hardie, D. Grahame,; Harrison, David J.,; Hayes, John D.,; Henderson, C.J.,; Hidalgo, Elena,; Huot, Jacques,; Jackson, Stephen P.,; Kyriakis, John M.,; Lakin, Nicholas D.,; Landry, Jacques,; Manson, Margaret M.,; Millar, Jonathan B.A.,; Morimoto, Richard I.,; Neal, Gordon E.,; Saklatvala, Jeremy,; Smith, A.G.,; Smith, G.,; Smith, Graeme C.M.,; Wolf, C.R.,
• HerausgeberIn: Downes, C. P.,; Lane, D. P.,; Wolf, C. R.,
• Place / Publishing House: Princeton, NJ : : Princeton University Press, , [2014]; ©1999
• Year of Publication: 2014
• Edition: Core Textbook
• Language: English
• Series: Princeton Legacy Library ; 85
• Physical Description: 1 online resource (184 p.)

Cellular Responses to Stress brings together a group of scientists who work on different but interrelated aspects of cellular stress responses. The book provides state-of-the-art information on the wide spectrum of ways in which cells can respond to different forms of stress induced by chemicals, oxidants, and DNA-damaging agents. Mechanisms are described that involve altered uptake and efflux of chemical agents, intracellular detoxification, and DNA damage responses. Many of these changes trigger a cascade of reactions mediated by stress-activated signaling pathways, which have the capacity to determine whether a cell will survive or die. The spectrum of topics covered in this book aims to provide a broad overview of our current knowledge of the different forms of adaptive response systems.It is hoped that this text will stimulate further research to establish the relative cellular role of specific response pathways and will enable us to gain a deeper understanding of the mechanisms that allow cells to live or die. This book will be valued by university researchers at all levels, industrial scientists in the pharmaceutical and biotechnology industries, and clinical researchers.Originally published in 1999.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Table of Contents

Frontmatter -- Contents -- Preface -- Abbreviations -- 1. Signal transduction by the c-Jun N-terminal kinase -- 2. Roles of the AMP-activated/SNFI protein kinase family in the response to cellular stress -- 3. Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses -- 4. Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts -- 5. Protein kinase cascades in intracellular signalling by interleukin-1 and tumour necrosis factor -- 6. Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27) -- 7 DNA-dependent protein kinase and related proteins -- 8. Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors -- 9. Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response -- 10. Adaptive responses to environmental chemicals -- 11. Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress -- Index