Biomolecular Feedback Systems / / Richard M. Murray, Domitilla Del Vecchio.

• Superior document: Title is part of eBook package: De Gruyter Princeton University Press Complete eBook-Package 2014-2015
• VerfasserIn: Del Vecchio, Domitilla,; Murray, Richard M.,
• Place / Publishing House: Princeton, NJ : : Princeton University Press, , [2014]; ©2015
• Year of Publication: 2014
• Edition: Course Book
• Language: English
• Physical Description: 1 online resource (288 p.) :; 13 halftones. 113 line illus. 3 tables
• Other title: Frontmatter --; Contents --; Preface --; Chapter 1. Introductory Concepts --; Chapter 2. Dynamic Modeling of Core Processes --; Chapter 3. Analysis of Dynamic Behavior --; Chapter 4. Stochastic Modeling and Analysis --; Chapter 5. Biological Circuit Components --; Chapter 6. Interconnecting Components --; Chapter 7. Design Tradeoffs --; Bibliography --; Index
• Format: Mode of access: Internet via World Wide Web.
• ISBN: 9781400850501; 9783110665925
• DOI: 10.1515/9781400850501?locatt=mode:legacy
• Access: restricted access
• Hierarchical level: Monograph
• Statement of Responsibility: Richard M. Murray, Domitilla Del Vecchio.

This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources.Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems.Provides a user-friendly introduction to essential concepts, tools, and applicationsCovers the most commonly used modeling methodsAddresses the modular design problem for biomolecular systemsUses design examples from both natural systems and synthetic circuitsSolutions manual (available only to professors at press.princeton.edu)An online illustration package is available to professors at press.princeton.edu