Robustness and Evolvability in Living Systems / / Andreas Wagner.

• Superior document: Title is part of eBook package: De Gruyter Princeton University Press eBook-Package Backlist 2000-2013
• VerfasserIn: Wagner, Andreas,
• Place / Publishing House: Princeton, NJ : : Princeton University Press, , [2013]; ©2005
• Year of Publication: 2013
• Edition: Course Book
• Language: English
• Series: Princeton Studies in Complexity ; 24
• Physical Description: 1 online resource (368 p.) :; 22 halftones. 51 line illus.

All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems...

Table of Contents

• Frontmatter
• Contents
• Figures
• Acknowledgments
• 1. Introduction
• PART I: ROBUSTNESS BELOW THE GENE LEVEL
• 2. The Genetic Alphabet
• 3. The Genetic Code
• 4. RNA Structure
• 5. Proteins and Point Mutations
• 6. Proteins and Recombination
• PART II: ROBUSTNESS ABOVE THE GENE LEVEL
• 7. Regulatory DNA Regions and Their Reorganization in Evolution
• 8. Metabolic Pathways
• 9. Metabolic Networks
• 10. Drosophila Segmentation and Other Gene Regulatory Networks
• 11. Phenotypic Traits, Cryptic Variation, and Human Diseases
• 12. The Many Ways of Building the Same Body
• PART III: COMMON PRINCIPLES
• 13. Neutral Spaces
• 14. Evolvability and Neutral Mutations
• 15. Redundancy of Parts or Distributed Robustness?
• 16. Robustness as an Evolved Adaptation to Mutations
• 17. Robustness as an Evolved Adaptation to Environmental Change and Noise
• 18. Robustness and Fragility: Advantages to Variation and Trade-offs
• PART IV: ROBUSTNESS BEYOND THE ORGANISM
• 19. Robustness in Natural Systems and Self-Organization
• 20. Robustness in Man-made Systems
• Epilogue: Seven Open Questions for Systems Biology
• Bibliography
• Index