Dynamics of Cancer : : Incidence, Inheritance, and Evolution / / Steven A. Frank.
The onset of cancer presents one of the most fundamental problems in modern biology. In Dynamics of Cancer, Steven Frank produces the first comprehensive analysis of how particular genetic and environmental causes influence the age of onset. The book provides a unique conceptual and historical frame...
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Place / Publishing House: | Princeton, NJ : : Princeton University Press, , [2018] ©2007 |
Year of Publication: | 2018 |
Language: | English |
Series: | Princeton Series in Evolutionary Biology ;
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Physical Description: | 1 online resource (400 p.) |
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Frank, Steven A., author. aut http://id.loc.gov/vocabulary/relators/aut Dynamics of Cancer : Incidence, Inheritance, and Evolution / Steven A. Frank. Princeton, NJ : Princeton University Press, [2018] ©2007 1 online resource (400 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Princeton Series in Evolutionary Biology ; 1 Frontmatter -- Contents -- 1. Introduction -- Part I: Background -- 2. Age of Cancer Incidence -- 3. Multistage Progression -- 4. History of Theories -- Part II: Dynamics -- 5. Progression Dynamics -- 6. Theory I -- 7. Theory II -- 8. Genetics of Progression -- 9. Carcinogens -- 10. Aging -- Part III: Evolution -- 11. Inheritance -- 12. Stem Cells: Tissue Renewal -- 13. Stem Cells: Population Genetics -- 14. Cell Lineage History -- 15. Conclusions -- Appendix: Incidence -- References -- Author Index -- Subject Index restricted access http://purl.org/coar/access_right/c_16ec online access with authorization star The onset of cancer presents one of the most fundamental problems in modern biology. In Dynamics of Cancer, Steven Frank produces the first comprehensive analysis of how particular genetic and environmental causes influence the age of onset. The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer. This is the only book that presents a full analysis of the age of cancer onset. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For cancer biologists, population geneticists, evolutionary biologists, and demographers interested in aging, this book provides new insight into disease progression, the inheritance of predisposition to disease, and the evolutionary processes that have shaped organismal design. Issued also in print. Mode of access: Internet via World Wide Web. In English. Description based on online resource; title from PDF title page (publisher's Web site, viewed 30. Aug 2021) Cancer Age factors. Cancer Epidemiology. Cancer Genetic aspects. Carcinogenesis. MEDICAL / Oncology. bisacsh Title is part of eBook package: De Gruyter Princeton University Press eBook-Package Backlist 2000-2013 9783110442502 print 9780691133669 https://doi.org/10.1515/9780691186863?locatt=mode:legacy https://www.degruyter.com/isbn/9780691186863 Cover https://www.degruyter.com/cover/covers/9780691186863.jpg |
language |
English |
format |
eBook |
author |
Frank, Steven A., Frank, Steven A., |
spellingShingle |
Frank, Steven A., Frank, Steven A., Dynamics of Cancer : Incidence, Inheritance, and Evolution / Princeton Series in Evolutionary Biology ; Frontmatter -- Contents -- 1. Introduction -- Part I: Background -- 2. Age of Cancer Incidence -- 3. Multistage Progression -- 4. History of Theories -- Part II: Dynamics -- 5. Progression Dynamics -- 6. Theory I -- 7. Theory II -- 8. Genetics of Progression -- 9. Carcinogens -- 10. Aging -- Part III: Evolution -- 11. Inheritance -- 12. Stem Cells: Tissue Renewal -- 13. Stem Cells: Population Genetics -- 14. Cell Lineage History -- 15. Conclusions -- Appendix: Incidence -- References -- Author Index -- Subject Index |
author_facet |
Frank, Steven A., Frank, Steven A., |
author_variant |
s a f sa saf s a f sa saf |
author_role |
VerfasserIn VerfasserIn |
author_sort |
Frank, Steven A., |
title |
Dynamics of Cancer : Incidence, Inheritance, and Evolution / |
title_sub |
Incidence, Inheritance, and Evolution / |
title_full |
Dynamics of Cancer : Incidence, Inheritance, and Evolution / Steven A. Frank. |
title_fullStr |
Dynamics of Cancer : Incidence, Inheritance, and Evolution / Steven A. Frank. |
title_full_unstemmed |
Dynamics of Cancer : Incidence, Inheritance, and Evolution / Steven A. Frank. |
title_auth |
Dynamics of Cancer : Incidence, Inheritance, and Evolution / |
title_alt |
Frontmatter -- Contents -- 1. Introduction -- Part I: Background -- 2. Age of Cancer Incidence -- 3. Multistage Progression -- 4. History of Theories -- Part II: Dynamics -- 5. Progression Dynamics -- 6. Theory I -- 7. Theory II -- 8. Genetics of Progression -- 9. Carcinogens -- 10. Aging -- Part III: Evolution -- 11. Inheritance -- 12. Stem Cells: Tissue Renewal -- 13. Stem Cells: Population Genetics -- 14. Cell Lineage History -- 15. Conclusions -- Appendix: Incidence -- References -- Author Index -- Subject Index |
title_new |
Dynamics of Cancer : |
title_sort |
dynamics of cancer : incidence, inheritance, and evolution / |
series |
Princeton Series in Evolutionary Biology ; |
series2 |
Princeton Series in Evolutionary Biology ; |
publisher |
Princeton University Press, |
publishDate |
2018 |
physical |
1 online resource (400 p.) Issued also in print. |
contents |
Frontmatter -- Contents -- 1. Introduction -- Part I: Background -- 2. Age of Cancer Incidence -- 3. Multistage Progression -- 4. History of Theories -- Part II: Dynamics -- 5. Progression Dynamics -- 6. Theory I -- 7. Theory II -- 8. Genetics of Progression -- 9. Carcinogens -- 10. Aging -- Part III: Evolution -- 11. Inheritance -- 12. Stem Cells: Tissue Renewal -- 13. Stem Cells: Population Genetics -- 14. Cell Lineage History -- 15. Conclusions -- Appendix: Incidence -- References -- Author Index -- Subject Index |
isbn |
9780691186863 9783110442502 9780691133669 |
url |
https://doi.org/10.1515/9780691186863?locatt=mode:legacy https://www.degruyter.com/isbn/9780691186863 https://www.degruyter.com/cover/covers/9780691186863.jpg |
illustrated |
Not Illustrated |
dewey-hundreds |
600 - Technology |
dewey-tens |
610 - Medicine & health |
dewey-ones |
616 - Diseases |
dewey-full |
616.99/4071 |
dewey-sort |
3616.99 44071 |
dewey-raw |
616.99/4071 |
dewey-search |
616.99/4071 |
doi_str_mv |
10.1515/9780691186863?locatt=mode:legacy |
oclc_num |
1076401709 |
work_keys_str_mv |
AT frankstevena dynamicsofcancerincidenceinheritanceandevolution |
status_str |
n |
ids_txt_mv |
(DE-B1597)502013 (OCoLC)1076401709 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Title is part of eBook package: De Gruyter Princeton University Press eBook-Package Backlist 2000-2013 |
is_hierarchy_title |
Dynamics of Cancer : Incidence, Inheritance, and Evolution / |
container_title |
Title is part of eBook package: De Gruyter Princeton University Press eBook-Package Backlist 2000-2013 |
_version_ |
1770176300646924288 |
fullrecord |
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